{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:20:05Z","timestamp":1790040005487,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:bold>The aim of this study was to determine canine breed predispositions for decreased serum folate or markedly decreased cobalamin concentrations.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:bold>Retrospective analysis of samples from dogs that had serum folate and cobalamin concentrations measured, from 1990 to 2002 at the Comparative Gastroenterology Laboratory of Liverpool, were enrolled. A total of 13,069 samples were analysed. Those with trypsin\u2010like immunoreactivity &lt;\u20095\u00b70\u2009lg\/L were excluded, and only breeds with at least 30 individuals tested were further analyzed. Breed predisposition was determined by calculating odds ratios and 95% confidence intervals for hypocobalaminaemia or decreased folate concentration. Significance was tested with a two\u2010sided Fisher's exact test, and the level of statistical significance was set at P&lt;0\u00b705.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold>A total of 9960 dogs fulfilled the inclusion criteria. Forty breeds contained at least 30 individuals. Predispositions for hypocobalaminaemia were identified in shar peis, Staffordshire bull terriers, German shepherd dogs and mixed breeds. Predispositions for decreased folate concentration were found in golden retrievers and boxers.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p><jats:bold>Predisposition for marked hypocobalaminaemia and decreased folate concentration differed between breeds. The shar peis had a markedly increased odds ratio for hypocobalaminaemia, as previously reported in North America, but other at\u2010risk breeds were also identified.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12039","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T22:12:53Z","timestamp":1362435173000},"page":"143-148","source":"Crossref","is-referenced-by-count":10,"title":["Canine breed predispositions for marked hypocobalaminaemia or decreased folate concentration assessed by a laboratory survey"],"prefix":"10.1111","volume":"54","author":[{"given":"J. R. S.","family":"Dandrieux","sequence":"first","affiliation":[{"name":"School of Veterinary Science University of Liverpool Neston Wirral"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. \u2010J. M.","family":"Noble","sequence":"additional","affiliation":[{"name":"School of Veterinary Science University of Liverpool Neston Wirral"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Halladay","sequence":"additional","affiliation":[{"name":"School of Veterinary Science University of Liverpool Neston Wirral"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"McLean","sequence":"additional","affiliation":[{"name":"School of Veterinary Science University of Liverpool Neston Wirral"},{"name":"Institute of Integrative Biology, Proteomics Group University of Liverpool Liverpool Wirral"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"German","sequence":"additional","affiliation":[{"name":"School of Veterinary Science University of Liverpool Neston Wirral"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03011.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb02928.x"},{"key":"e_1_2_6_4_1","first-page":"G344","article-title":"Gastric and pancreatic intrinsic factor\u2010mediated absorption of cobalamin in the dog","volume":"257","author":"Batt R. M.","year":"1989","journal-title":"American Journal of Physiology"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1991.tb00552.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2005.tb00330.x"},{"key":"e_1_2_6_7_1","first-page":"613","volume-title":"Partial characterization of cobalamin deficiency in Chinese shar peis","author":"Bishop M. A.","year":"2012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i24.2978"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0427.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.12.1437"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/124.suppl_12.2559S"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199101000-00006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb01321.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esp100"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638712461250"},{"key":"e_1_2_6_16_1","first-page":"1526","volume-title":"Textbook of Veterinary Internal Medicine","author":"Hall E. J.","year":"2010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1197"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2000.tb03233.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2011.05157.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.8.1194"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/S0021-9258(19)85955-0","article-title":"Preparation and characterization of proteins in the alimentary tract of the dog which bind cobalamin and intrinsic factor","volume":"255","author":"Marcoullis G.","year":"1980","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-35-5-392"},{"key":"e_1_2_6_23_1","first-page":"169","volume-title":"Hereditary cobalamin deficiency in Border collie dogs","author":"Outerbridge C. A.","year":"1996"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2460\/javma.1995.206.02.187","article-title":"Small intestinal bacterial overgrowth in dogs with chronic intestinal disease","volume":"206","author":"Rutgers H. C.","year":"1995","journal-title":"Journal of American Veterinary Medical Association"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2010.04.008"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2460\/ajvr.1989.50.05.629","article-title":"Circulating concentration of trypsin\u2010like immunoreactivity and activities of lipase and amylase after pancreatic duct ligation in dogs","volume":"50","author":"Simpson K. W.","year":"1989","journal-title":"Americacn Journal of Veterinary Research"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.163.21.621"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1939-1676.1999.tb01458.x","article-title":"Serum trypsinlike immunoreactivity measurement for the diagnosis of subclinical exocrine pancreatic insufficiency","volume":"13","author":"Wiberg M. E.","year":"1991","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"e_1_2_6_29_1","first-page":"133","volume-title":"Markedly subnormal serum cobalamin in Shar\u2010Pei dogs with signs of gastrointestinal disease","author":"Williams D. A.","year":"1991"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsap.12039","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsap.12039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.12039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T22:54:55Z","timestamp":1745967295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.12039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/jsap.12039"],"URL":"https:\/\/doi.org\/10.1111\/jsap.12039","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}