{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:27:50Z","timestamp":1790087270962,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,13]],"date-time":"2013-07-13T00:00:00Z","timestamp":1373673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:bold>To determine whether methadone, administered before orthopaedic surgery, results in improved postoperative analgesia compared to buprenorphine.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:bold>Thirty\u2010eight dogs undergoing orthopaedic surgeries (the majority being tibial tuberosity advancement or elbow arthrotomy) were premedicated with 0\u2009\u00b7\u200903\u2009mg\/kg acepromazine and either 20\u2009\u00b5g\/kg buprenorphine or 0\u2009\u00b7\u20095\u2009mg\/kg methadone, intramuscularly, allocated randomly. Anaesthesia was induced with propofol intravenously to effect and maintained with isoflurane in oxygen. 0\u2009\u00b7\u20092\u2009mg\/kg meloxicam was administered at anaesthetic induction. Sedation was assessed by means of a dynamic interactive visual analogue and simple descriptive scales and pain by dynamic interactive visual analogue and the short form Glasgow composite pain scales, by a single observer blinded to treatment group at intervals for 8\u2009hours following premedication.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold>Sedation scores were higher than baseline in both groups following premedication until the end of the assessment period (P\u2009=\u20090\u2009\u00b7\u20090001), with no differences between groups. Pain scores were lower overall in dogs premedicated with methadone (dynamic interactive visual analogue scale P\u2009=\u20090\u2009\u00b7\u2009048; short form Glasgow composite pain scale P\u2009=\u20090\u2009\u00b7\u20090045), and these dogs required less additional analgesia (42%, compared to 79% premedicated with buprenorphine, P\u2009=\u20090\u2009\u00b7\u2009045).<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p><jats:bold>At the doses investigated, methadone produced superior analgesia to buprenorphine for 8\u2009hours postoperatively in dogs undergoing orthopaedic surgery.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12103","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T17:54:58Z","timestamp":1374688498000},"page":"418-424","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of premedication with buprenorphine or methadone with meloxicam for postoperative analgesia in dogs undergoing orthopaedic surgery"],"prefix":"10.1111","volume":"54","author":[{"given":"J. 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