{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:19:04Z","timestamp":1789067944259,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T00:00:00Z","timestamp":1374624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:bold>To assess survival and risk factors in dogs with pulmonic stenosis.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:bold>A retrospective review of medical case records of all cases of pulmonic stenosis &gt;50<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content>, undergoing pulmonary balloon valvuloplasty or not. Survival curves and multivariate analysis were calculated in the overall population and in subgroups.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold>One hundred and seventy\u2010two cases were included. Factors negatively affecting survival were clinical signs [hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 3\u2009\u00b7\u200944, P\u2009&lt;\u20090\u2009\u00b7\u2009001], younger age at diagnosis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>3\u2009\u00b7\u200996, P\u2009=\u20090\u2009\u00b7\u2009001) and valve morphology type B (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>3\u2009\u00b7\u200933, P\u2009=\u20090\u2009\u00b7\u2009001) in the overall population. In those that had pulmonary balloon valvuloplasty group only clinical signs was significant (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>3\u2009\u00b7\u200944, P\u2009&lt;\u20090\u2009\u00b7\u2009001). In cases that did not undergo pulmonary balloon valvuloplasty group Doppler gradient (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>1\u2009\u00b7\u200902, P\u2009&lt;\u20090\u2009\u00b7\u2009001), clinical signs (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>5\u2009\u00b7\u200941, P\u2009=\u20090\u2009\u00b7\u2009002), valve morphology type B (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>10\u2009\u00b7\u200920, P\u2009=\u20090\u2009\u00b7\u2009001) and younger age at diagnosis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>12\u2009\u00b7\u200982, P\u2009&lt;\u20090\u2009\u00b7\u2009001) negatively affected survival. Dogs with severe pulmonic stenosis undergoing pulmonary balloon valvuloplasty (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>0\u2009\u00b7\u200947, P\u2009=\u20090\u2009\u00b7\u2009047) and asymptomatic dogs with moderate pulmonic stenosis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>0\u2009\u00b7\u200910, P\u2009=\u20090\u2009\u00b7\u2009042) had a better outcome. Younger age at diagnosis was correlated with poorer outcome in right\u2010sided congestive heart failure dogs (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>14\u2009\u00b7\u200902, P\u2009=\u20090\u2009\u00b7\u200901).<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p><jats:bold>Clinical signs, valve morphology type B and age at diagnosis are risk factors in pulmonic stenosis patients. Pulmonary balloon valvuloplasty is a reasonable treatment choice in dogs with severe pulmonic stenosis.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12113","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T20:54:28Z","timestamp":1374699268000},"page":"445-452","source":"Crossref","is-referenced-by-count":60,"title":["Pulmonic stenosis in dogs: survival and risk factors in a retrospective cohort of patients"],"prefix":"10.1111","volume":"54","author":[{"given":"C.","family":"Locatelli","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Veterinarie e Salute Pubblica Universit\u00e0 degli Studi di Milano via Celoria 10 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Spalla","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Veterinarie e Salute Pubblica Universit\u00e0 degli Studi di Milano via Celoria 10 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Domenech","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso Via Donatello 26 20131 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sala","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera di Busto Arsizio Universit\u00e0 degli Studi di Milano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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