{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:34:43Z","timestamp":1778589283247,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T00:00:00Z","timestamp":1377216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:bold>To evaluate the efficacy and safety of topiramate as an add\u2010on therapy in dogs with refractory idiopathic epilepsy<\/jats:bold>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p><jats:bold>Prospective, open label, non\u2010comparative clinical trial of topiramate in dogs with idiopathic epilepsy and poor seizure control despite therapeutic serum concentrations of phenobarbital and potassium bromide. The efficacy of topiramate was evaluated by comparing seizure and seizure day frequencies during a retrospective 2\u2010month period with a prospective short\u2010term follow\u2010up of 6 months. An additional long\u2010term follow\u2010up period ranging from 3 to 9 months was conducted on dogs that responded to topiramate therapy during the short\u2010term follow\u2010up<\/jats:bold>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold>Ten dogs were included. Five (50%) responded to topiramate therapy during the short\u2010term follow\u2010up showing a significant (P=0\u00b704) decrease of 66% in seizure frequency. Three of the five dogs remained responders during the long\u2010term follow\u2010up. Weight loss, sedation and ataxia were the most common adverse effects of topiramate therapy, but in dogs with moderate sedation or ataxia, signs subsided in a few weeks to few months to mild sedation or ataxia<\/jats:bold>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p><jats:bold>Topiramate may be effective as an add\u2010on medication in treating canine idiopathic epilepsy. Apart from sedation and ataxia reported in some of the dogs, topiramate was well\u2010tolerated<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12130","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T06:52:47Z","timestamp":1377240767000},"page":"512-520","source":"Crossref","is-referenced-by-count":15,"title":["Topiramate as an add\u2010on antiepileptic drug in treating refractory canine idiopathic epilepsy"],"prefix":"10.1111","volume":"54","author":[{"given":"A.\u2010M.","family":"Kiviranta","sequence":"first","affiliation":[{"name":"Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine University of Helsinki FI\u201000014 Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Laitinen\u2010Vapaavuori","sequence":"additional","affiliation":[{"name":"Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine University of Helsinki FI\u201000014 Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hielm\u2010Bj\u00f6rkman","sequence":"additional","affiliation":[{"name":"Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine University of Helsinki FI\u201000014 Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Jokinen","sequence":"additional","affiliation":[{"name":"Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine University of Helsinki FI\u201000014 Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.153.1.13"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03017.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1330"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.10093"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03190614"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00203.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2006.05.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5326\/0400285"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.12.1442"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb02169.x"},{"key":"e_1_2_6_12_1","unstructured":"D. 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