{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:10Z","timestamp":1787015590392,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>\n                    A six\u2010year\u2010old mixed\u2010breed male dog weighing 7.0\u2009kg was presented with chronic vomiting and regurgitation. Endoscopic examination revealed prominent oesophageal dilation in the thoracic region, multiple small greyish\u2010white nodules over the oesophageal lumen and cauliflower\u2010like masses in the caudal oesophagus. Histopathological studies revealed a characteristic pattern of coexisting elements of infiltrating adenocarcinoma and squamous cell carcinoma. Immunohistochemical staining with anti\u2010cytokeratin\n                    <jats:styled-content style=\"fixed-case\">AE1<\/jats:styled-content>\n                    \u2009+\u2009\n                    <jats:styled-content style=\"fixed-case\">AE3<\/jats:styled-content>\n                    was positive in both types of neoplastic cells. Neoplastic glandular cells stained positively for cytokeratin 8 while neoplastic squamous cells stained positively for cytokeratin 5\/6. On the basis of these findings, the dog was diagnosed with oesophageal adenosquamous carcinoma. The case history and findings suggest that the malignancy might have developed from Barrett's oesophagus following irritation of the oesophageal mucosa due to chronic vomiting and regurgitation.\n                  <\/jats:p>","DOI":"10.1111\/jsap.12333","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T02:41:20Z","timestamp":1422326480000},"page":"521-523","source":"Crossref","is-referenced-by-count":7,"title":["Adenosquamous carcinoma of the oesophagus in a dog"],"prefix":"10.1111","volume":"56","author":[{"given":"H.","family":"Okanishi","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Bioresource Sciences Nihon University Fujisawa Kanagawa 252\u20100880 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Bioresource Sciences Nihon University Fujisawa Kanagawa 252\u20100880 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Bioresource Sciences Nihon University Fujisawa Kanagawa 252\u20100880 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Asano","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Bioresource Sciences Nihon University Fujisawa Kanagawa 252\u20130880 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sato","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Bioresource Sciences Nihon University Fujisawa Kanagawa 252\u20100880 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Watari","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Bioresource Sciences Nihon University Fujisawa Kanagawa 252\u20100880 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003815005"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.04.023"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90642-8"},{"key":"e_1_2_4_5_1","first-page":"92","article-title":"Some aetiological aspects of tumours in domesticated animals","volume":"38","author":"Cotchin E.","year":"1966","journal-title":"Annals of the Royal College of Surgeons of England"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985809352973"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376928.ch8"},{"key":"e_1_2_4_8_1","first-page":"47","article-title":"Esophageal sarcomas associated with canine spirocercosis","volume":"73","author":"Ivoghli B.","year":"1978","journal-title":"Veterinary Medicine and Small Animal Clinician"},{"key":"e_1_2_4_9_1","first-page":"561","article-title":"Squamous cell carcinoma of the esophagus in a dog","volume":"16","author":"McCaw D.","year":"1980","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02913171"},{"key":"e_1_2_4_11_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2460\/javma.1984.184.01.98","article-title":"Hypertrophic osteopathy associated with adenocarcinoma of the esophageal glands in a dog","volume":"184","author":"Randolph J. 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