{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:44:36Z","timestamp":1790120676430,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,28]],"date-time":"2015-03-28T00:00:00Z","timestamp":1427500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To evaluate the activity and tolerability of three\u2010dimensional conformal radiation therapy (<jats:styled-content style=\"fixed-case\">3D\u2010CRT<\/jats:styled-content>) in dogs with massive hepatocellular carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>MATERIALS AND METHODS<\/jats:title><jats:p>Six dogs with massive hepatocellular carcinoma that were ineligible for surgical resection or with owners who declined surgical resection, and underwent <jats:styled-content style=\"fixed-case\">3D\u2010CRT<\/jats:styled-content> were retrospectively reviewed. 6 to 10 Gy per fraction was prescribed at isocentre of planning target volume to a total dose of 18 to 42 Gy with 1 to 2 fractions per week for a total of 3 to 7 fractions. Follow\u2010up examinations included physical examination, contrast\u2010enhanced <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scan and blood analysis (complete blood count, electrolytes and serum biochemical panel).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The median follow\u2010up time after <jats:styled-content style=\"fixed-case\">3D\u2010CRT<\/jats:styled-content> was 534 (range, 281 to 1057) days. An objective response was observed in five of six cases. Radiation\u2010induced liver disease developed in one dog but was asymptomatic and reversible. Toxicity was not noted in any other dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>CLINICAL SIGNIFICANCE<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">3D\u2010CRT<\/jats:styled-content> appears to be a viable treatment option for dogs with inoperable massive hepatocellular carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12352","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T06:00:33Z","timestamp":1427608833000},"page":"441-445","source":"Crossref","is-referenced-by-count":18,"title":["Three\u2010dimensional conformal radiation therapy for inoperable massive hepatocellular carcinoma in six dogs"],"prefix":"10.1111","volume":"56","author":[{"given":"T.","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences Gifu University  1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences Gifu University  1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kawabe","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences Gifu University  1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences Gifu University  1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Applied Biological Sciences Gifu University  1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences Gifu University  1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Maruo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences Gifu University  1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.09.053"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02915-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01994.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02846-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21811"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1582"},{"key":"e_1_2_5_9_1","first-page":"200","article-title":"Radiation hepatitis","volume":"93","author":"Ingold J. 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