{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:00:32Z","timestamp":1774425632388,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To determine the effect of 1% brinzolamide, 2% dorzolamide hydrochloride or combination 2% dorzolamide hydrochloride\/0 \u00b7 5% timolol to delay the elevation of the intraocular pressure in second eyes of dogs with primary closed\u2010angle glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Analysis of retrospectively collated data from 40 dogs with primary closed\u2010angle glaucoma, where the non\u2010affected eye was treated prophylactically with brinzolamide (n = 10), dorzolamide (n = 18) or combination dorzolamide\/timolol therapy (n = 12).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The 40 treated dogs (median age of 76 \u00b7 2 months) comprised 25 females\/15 males, 19 entire\/21 neutered. Twenty dogs developed glaucoma in the contralateral eye (median time of 9 \u00b7 2 months). No statistically significant difference was identified during treatment failure between the treatment groups (P = 0 \u00b7 66). The second eye remained normotensive in 20 dogs; four dogs until the conclusion of the study (median: 27 \u00b7 0 months), three dogs until death (median: 15 \u00b7 4 months), seven dogs until lost to follow\u2010up (median: 11 \u00b7 6 months). Out of these 20 dogs, treatment was discontinued because of lack of owner compliance in two dogs and following a local drug reaction in four dogs (median: 8 \u00b7 9 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>CLINICAL SIGNIFICANCE<\/jats:title><jats:p>There was no evidence that the tested drugs delayed elevation of intraocular pressure in contralateral eyes of dogs with primary closed\u2010angle glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12393","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T06:58:07Z","timestamp":1441263487000},"page":"662-666","source":"Crossref","is-referenced-by-count":6,"title":["The effect of prophylactic topical carbonic anhydrase inhibitors in canine primary closed\u2010angle glaucoma"],"prefix":"10.1111","volume":"56","author":[{"given":"R.","family":"Stavinohova","sequence":"first","affiliation":[{"name":"Comparative Ophthalmology Unit, Animal Health Trust Lanwades Park Kentford Newmarket CB8 7UU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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