{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:30:25Z","timestamp":1791639025795,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of this study were to describe the efficacy, outcome and adverse effects of intravenous hydrocortisone and fluid therapy for the management of acute hypoadrenocorticism in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of dogs with primary hypoadrenocorticism receiving intravenous hydrocortisone and fluid therapy was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty newly\u2010diagnosed dogs were included. There was an excellent clinical response, with all dogs surviving to discharge within a median of 2 days. In 23 cases with complete data, the mean rate of change of sodium over 24 hours was 0\u00b748 (\u00b10\u00b728) mmol\/L\/hour, while the mean rate of change of potassium was \u22120\u00b712 (\u00b10\u00b706) mmol\/L\/hour. Circulating potassium concentration normalised in 68\u00b74% and 100% of cases of by 12 and 24 hours, respectively. Additional treatment for hyperkalaemia was not found necessary. Plasma sodium concentration increased by &gt;12\u2009mmol\/L\/24\u2009hours on 7 of 23 (30\u00b74%) occasions. One dog exhibited associated temporary neurological signs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Intravenous hydrocortisone infusion and fluid therapy for the management of acute hypoadrenocorticism is associated with a rapid resolution of hyperkalaemia and is well tolerated with few adverse effects. Regular electrolyte monitoring is required to ensure that rapid increases in sodium concentration are avoided.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12473","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T17:29:05Z","timestamp":1461259745000},"page":"227-233","source":"Crossref","is-referenced-by-count":13,"title":["Hydrocortisone in the management of\u00a0acute hypoadrenocorticism in dogs: a\u00a0retrospective series of 30 cases"],"prefix":"10.1111","volume":"57","author":[{"given":"E.","family":"Gunn","sequence":"first","affiliation":[{"name":"Small Animal Clinical Studies, School of Veterinary Medicine University College Dublin Belfield Dublin 4 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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