{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:51:25Z","timestamp":1763747485856,"version":"3.41.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of this study were to establish a magnetic resonance imaging\u2010based classification system for canine hyperadrenocorticism according to pituitary gland extension, determine indications for trans\u2010sphenoidal hypophysectomy, and clarify the prognosis for each disease grade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 5\u2010point classification system (Grades 1 to 5) was developed based on tumour extension in dorsal and cranio\u2013caudal directions. Cases were then classified as Type A: no arterial circle of Willis or cavernous sinus involvement and Type B: cases in which these blood vessels were involved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Medical records and magnetic resonance imaging data of 37 cases with hyperadrenocorticism were reviewed. Thirty\u2010three cases underwent surgery; 4 Grade 5 cases did not have appropriate indications for surgery, and other therapies were used. Complete resection was achieved for 3, 3, 22 and 1 Grade<jats:styled-content style=\"fixed-case\">1A<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">2A<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">3A<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">3B<\/jats:styled-content>cases, respectively. Resection was incomplete in 1, 1 and 2 Grade<jats:styled-content style=\"fixed-case\">3A<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">3B<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">4B<\/jats:styled-content>cases, respectively. Remission was achieved in 29 cases. Recurrence occurred in 4 cases, all of which were classified as Grade 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Dogs with Type A, Grade 1 to 3 hyperadrenocorticism had a good prognosis following trans\u2010sphenoidal hypophysectomy. Grade<jats:styled-content style=\"fixed-case\">3B<\/jats:styled-content>, 4 and 5 cases may not be suitable for this surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12474","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T17:29:03Z","timestamp":1461259743000},"page":"240-246","source":"Crossref","is-referenced-by-count":15,"title":["A magnetic resonance imaging\u2010based classification system for indication of trans\u2010sphenoidal hypophysectomy in canine pituitary\u2010dependent hypercortisolism"],"prefix":"10.1111","volume":"57","author":[{"given":"A.","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine Nippon Veterinary and Life Science University 1\u20107\u20101 Kyonan\u2010cho Tokyo 180\u20108602 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Teshima","sequence":"additional","affiliation":[{"name":"Division of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine Nippon Veterinary and Life Science University 1\u20107\u20101 Kyonan\u2010cho Tokyo 180\u20108602 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ishino","sequence":"additional","affiliation":[{"name":"Laboratory of Small Animal Surgery 1, School of Veterinary Medicine Kitasato University 35\u20101 Higashi23ban\u2010cho Aomori 034\u20108628 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Harada","sequence":"additional","affiliation":[{"name":"Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine Nippon Veterinary and Life Science University 1\u20107\u20101 Kyonan\u2010cho Tokyo 180\u20108602 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yogo","sequence":"additional","affiliation":[{"name":"Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine Nippon Veterinary and Life Science University 1\u20107\u20101 Kyonan\u2010cho Tokyo 180\u20108602 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kanno","sequence":"additional","affiliation":[{"name":"Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine Nippon Veterinary and Life Science University 1\u20107\u20101 Kyonan\u2010cho Tokyo 180\u20108602 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Veterinary Radiology, Department of Veterinary Science, Faculty of Veterinary Medicine Nippon Veterinary and Life Science University 1\u20107\u20101 Kyonan\u2010cho Tokyo 180\u20108602 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hara","sequence":"additional","affiliation":[{"name":"Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine Nippon Veterinary and Life Science University 1\u20107\u20101 Kyonan\u2010cho Tokyo 180\u20108602 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.4.409"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030461"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.64"},{"key":"e_1_2_6_5_1","first-page":"252","volume-title":"Canine and Feline Endocrinology and Reproduction","author":"Feldman E. 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