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After 2 months, pulmonic stenosis was diagnosed, and the dog commenced treatment with oral atenolol; the ophthalmological disease worsened dramatically within a few days. The ophthalmic signs rapidly improved after discontinuation of atenolol, and there was bilateral complete remission after 3 weeks. No oral \u03b2\u2010blocker therapy was reintroduced, and thereafter, keratoconjunctivitis sicca was well\u2010controlled with topical therapy.<\/jats:p>","DOI":"10.1111\/jsap.12477","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T07:09:56Z","timestamp":1460531396000},"page":"379-381","source":"Crossref","is-referenced-by-count":1,"title":["Keratoconjunctivitis sicca exacerbation in a dog treated with systemic atenolol"],"prefix":"10.1111","volume":"57","author":[{"given":"G.","family":"Barsotti","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences University of Pisa Via Livornese (lato monte) 56122 San Piero a Grado Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Vezzosi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Pisa Via Livornese (lato monte) 56122 San Piero a Grado Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"343","article-title":"The effect of oral treatment with beta blockers on the tear secretion","volume":"6","author":"Almog Y.","year":"1982","journal-title":"Metabolic, Pediatric & Systemic Ophthalmology"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1760-2734(06)70007-8"},{"key":"e_1_2_4_4_1","first-page":"683","article-title":"The causes, diagnosis, and treatment of canine keratoconjunctivitis sicca","volume":"97","author":"Carter R.","year":"2002","journal-title":"Veterinary Medicine"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1634"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01059.x"},{"key":"e_1_2_4_7_1","first-page":"875","article-title":"Effects of short\u2010term oral administration of propranolol on tear secretion in clinically normal dogs","volume":"52","author":"Ghaffari M. 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