{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:44:48Z","timestamp":1771065888379,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Robmar Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Cardiac involvement in the course of acute kidney injury is described in humans as cardiorenal syndrome type 3 but has received only limited attention in dogs. This study was designed to evaluate cardiac injury and dysfunction in acute kidney injury in dogs and its association with outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This prospective cohort study enrolled 24 client\u2010owned dogs with acute kidney injury. Cardiac disorders were evaluated with thoracic radiographs, echocardiography, 24\u2010hour Holter monitoring and cardiac troponin I concentrations within 2 days of admission and 7 to 10 days later.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Most dogs were diagnosed with leptospirosis (n=18, 75%) and presented with moderate\u2010to\u2010severe acute kidney injury, International Renal Interest Society grades III to V. Dogs with \u00ea100 ventricular premature complexes per 24 hour in the first examination (n=8) had significantly higher initial cTnI concentrations (P=0\u00b7007) compared to dogs with fewer than 100. In receiver operating characteristic curve analysis, the number of ventricular premature complexes was predictive of outcome (AUC 0\u00b783, P&lt;0\u00b7001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CLINICAL SIGNIFICANCE<\/jats:title><jats:p>Acute kidney injury seems to be associated with cardiac injury and arrhythmias in dogs. The data do not indicate a cardiac cause of poor outcome in dogs with increased number of ventricular premature complexes but the association may reflect the severity of disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12495","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T09:37:20Z","timestamp":1467279440000},"page":"402-408","source":"Crossref","is-referenced-by-count":13,"title":["Evidence of cardiac injury and arrhythmias in dogs with acute kidney injury"],"prefix":"10.1111","volume":"57","author":[{"given":"S. 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