{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:30:14Z","timestamp":1778279414520,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The effects of lidocaine, administered before induction of anaesthesia with propofol, on arterial blood pressure, heart rate, respiratory rate, cough reflex, ease of intubation, extrapyramidal signs and required dose of propofol in healthy premedicated dogs were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty\u2010four client\u2010owned dogs were premedicated intramuscularly with 1 \u00b5g\/kg dexmedetomidine and 0\u00b72 mg\/kg methadone, and randomly allocated to receive 2 mg\/kg lidocaine (group L) or saline (group P) 120 seconds before induction of anaesthesia with propofol. Heart rate, non\u2010invasive arterial blood pressure and respiratory rate were assessed at pre\u2010established intervals. Quality of intubation, cough reflex and the occurrence of adverse effects were scored according to predefined scales. The total amount of propofol administered was also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Cardiovascular and respiratory variables changed over time but were not significantly different between treatments. No significant differences between groups were found for the incidence of coughing, quality of intubation, adverse effects and propofol intubation dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>CLINICAL SIGNIFICANCE<\/jats:title><jats:p>Intravenous administration of lidocaine 2 mg\/kg before propofol induction was not associated with significant cardiovascular and respiratory benefits compared to standard induction and did not result in a propofol dose\u2010sparing effect or improvement of the quality of intubation in dogs premedicated with dexmedetomidine and methadone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12502","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T04:49:58Z","timestamp":1464842998000},"page":"435-440","source":"Crossref","is-referenced-by-count":7,"title":["The effects of intravenous lidocaine before propofol induction in premedicated dogs"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-9676","authenticated-orcid":false,"given":"I.","family":"Cerasoli","sequence":"first","affiliation":[{"name":"Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine Ghent University  Merelbeke 9820 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nannarone","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Veterinaria, Centro dello Studio del Cavallo Sportivo Veterinary Teaching Hospital Universit\u00e0 degli Studi di Perugia  Perugia 06126 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Schauvliege","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine Ghent University  Merelbeke 9820 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Duchateau","sequence":"additional","affiliation":[{"name":"Department of Comparative Physiology and Biometrics, Faculty of Veterinary Medicine Ghent University  Merelbeke 9820 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bufalari","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine Ghent University  Merelbeke 9820 Belgium"},{"name":"Dipartimento di Medicina Veterinaria, Centro dello Studio del Cavallo Sportivo Veterinary Teaching Hospital Universit\u00e0 degli Studi di Perugia  Perugia 06126 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000247884.94119.d5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.06.018"},{"key":"e_1_2_5_4_1","first-page":"179","article-title":"Prophylactic effects of lidocaine or beclomethasone spray on post\u2010operative sore throat and cough after orotracheal intubation","volume":"27","author":"Banihashem N.","year":"2015","journal-title":"Iranian Journal of Otorhinolaryngology"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.5326\/0430008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12172"},{"key":"e_1_2_5_7_1","first-page":"1037","article-title":"Lack of effect of intravenous lidocaine on haemodynamic responses to rapid sequence induction of general anesthesia: a double\u2010blind controlled clinical trial","volume":"65","author":"Chraemmer\u2010J\u00f8rgensen B.","year":"1986","journal-title":"Anesthesia and Analgesia"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.1991.tb00014.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2012.00711.x"},{"key":"e_1_2_5_10_1","first-page":"211","article-title":"Evaluation of oscillometric and Doppler ultrasonic methods of indirect blood pressure estimation in conscious dogs","volume":"70","author":"Haberman C. 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