{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:01:11Z","timestamp":1770220871102,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To describe the clinical and pathological features of canine focal lipogranulomatous lymphangitis, to evaluate its underlying infectious cause and to compare it with human Crohn's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Retrospective review of case records with a histopathological diagnosis of focal lipogranulomatous lymphangitis. Bacterial and fungal colonisation was evaluated using fluorescence in situ hybridisation and histochemical staining, respectively. A comparison with Crohn's disease was performed by a human pathologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Ten dogs were evaluated. The historical complaints were predominantly chronic diarrhoea (10\/10) and vomiting (5\/10). The biochemical abnormalities included hypoalbuminaemia (6\/10) and hypocobalaminaemia (4\/6). Abdominal sonography revealed a thickened distal ileum\u00b1ileocolic junction. Colonoscopy showed a swollen caecal ostium and oedematous caecum in 7\/10 dogs. A stenotic ileo\u2010colic opening prevented endoscopic intubation in all dogs. Histology from the resected lesions revealed granulomatous inflammation involving the muscularis and serosa. Fluorescence in situ hybridization demonstrated invasive bacteria in 2\/10 dogs. Post\u2010resection, all dogs received metronidazole and tapering immunosuppressive doses of prednisolone. Remission (median 17 months) was achieved in 8\/10 dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>CLINICAL SIGNIFICANCE<\/jats:title><jats:p>Focal lipogranulomatous lymphangitis is a rare and severe form of canine inflammatory bowel disease with preferential localisation to the ileum and the ileocolic junction. An underlying infectious aetiology was not identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12522","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T16:58:37Z","timestamp":1467305917000},"page":"465-471","source":"Crossref","is-referenced-by-count":18,"title":["Focal intestinal lipogranulomatous lymphangitis in 10 dogs"],"prefix":"10.1111","volume":"57","author":[{"given":"A.","family":"Lecoindre","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, VetAgro Sup Campus V\u00e9t\u00e9rinaire Universit\u00e9 de Lyon  69280 Marcy l'Etoile 69007 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lecoindre","sequence":"additional","affiliation":[{"name":"CVC Clinique des Cerisioz  Route de Saint\u2010Symphorien\u2010d'Ozon 69800 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Cador\u00e9","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine interne, VetAgro Sup Campus V\u00e9t\u00e9rinaire Universit\u00e9 de Lyon  69280 Marcy l'Etoile 69007 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chevallier","sequence":"additional","affiliation":[{"name":"Laboratoire Biomnis  17\/19 avenue Tony Garnier 69007 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Guerret","sequence":"additional","affiliation":[{"name":"Laboratoire Biomnis  17\/19 avenue Tony Garnier 69007 Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Derr\u00e9","sequence":"additional","affiliation":[{"name":"Clinique V\u00e9t\u00e9rinaire de la Plage  1 Promenade George Pompidou 13008 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Mcdonough","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine Cornell University  Ithaca New York 14853 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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