{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:50:56Z","timestamp":1788511856879,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Treatment of canine idiopathic eosinophilic bronchopneumopathy mainly consists of long\u2010term oral corticosteroid therapy. To avoid side effects, inhaled steroid therapy has been increasingly used but long\u2010term clinical response and potential side effects are sparsely described.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Description of clinical response and side effects with long\u2010term fluticasone in dogs with eosinophilic bronchopneumopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Case series of dogs with eosinophilic bronchopneumopathy and treated with fluticasone monotherapy for at least 6 months. Clinical response and side effects assessed by physical examination, standardised questionnaire and <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> (corticotropin) stimulation test.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Eight dogs were treated for between 6 months and 5 years. Cough initially improved in all dogs; two dogs remained free of clinical signs, three were well controlled, but three showed severe relapse. Pituitary\u2013adrenal axis inhibition occurred in two dogs treated with fluticasone monotherapy for more than 2 years; only one dog had clinical signs of iatrogenic hyperadrenocorticism.<\/jats:p><\/jats:sec><jats:sec><jats:title>CLINICAL SIGNIFICANCE<\/jats:title><jats:p>Fluticasone monotherapy allows initial improvement or remission in the majority of dogs but long\u2010term treatment fails to resolve the cough in some individuals. In addition, such therapy may induce pituitary\u2010adrenal axis inhibition. Prospective larger and randomised studies including both fluticasone and orally\u2010treated dogs are needed to define the optimal treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12529","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T15:46:51Z","timestamp":1469720811000},"page":"537-542","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010term follow\u2010up in dogs with idiopathic eosinophilic bronchopneumopathy treated with inhaled steroid therapy"],"prefix":"10.1111","volume":"57","author":[{"given":"A.M.","family":"Canonne","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Internal Medicine Faculty of Veterinary Medicine, University of Li\u00e8ge  Li\u00e8ge 4000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bolen","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Diagnostic Imaging Faculty of Veterinary Medicine, University of Li\u00e8ge  Li\u00e8ge 4000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Internal Medicine Faculty of Veterinary Medicine, University of Li\u00e8ge  Li\u00e8ge 4000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Billen","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Internal Medicine Faculty of Veterinary Medicine, University of Li\u00e8ge  Li\u00e8ge 4000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Clercx","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Internal Medicine Faculty of Veterinary Medicine, University of Li\u00e8ge  Li\u00e8ge 4000 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12070"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60683-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00028.x"},{"key":"e_1_2_5_5_1","unstructured":"Canonne\u2010Guibert M. 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