{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:48:17Z","timestamp":1790786897951,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The clinical feasibility of passive immunotherapy has not been demonstrated in dogs naturally infected with canine distemper. In this study, porcine anti\u2010canine distemper virus <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> and F(ab\u2032)<jats:sub>2<\/jats:sub> antibody fragments were used to treat infected puppies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 41 naturally infected puppies (age \u00c4six months) exhibiting severe respiratory signs, but lacking neurological signs, were enrolled in the study. Twenty\u2010five puppies were treated with a combination of <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> or F(ab\u2032)<jats:sub>2<\/jats:sub> antibody fragments (Group 1) and supportive therapy and 16 puppies received routine supportive care only (Group 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The survival rate of dogs in Group 1 (19\/25; 76%) was significantly higher than that in Group 2 (5\/16; 31\u00b73%) (P&lt;0\u00b705). During the therapy, 8 of the 25 dogs (32%) in Group 1 developed neurological signs <jats:italic>versus<\/jats:italic> 12 of the 16 dogs (75%) in Group 2 (P&lt;0\u00b705). Adverse reactions were limited to elevated body temperature in dogs that received <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Porcine anti\u2010canine distemper virus antibodies improved survival in puppies affected with canine distemper with minimal adverse effects. Therefore, this therapy could be considered for treatment of endangered animal species infected with canine distemper virus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12557","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T15:26:27Z","timestamp":1476372387000},"page":"626-630","source":"Crossref","is-referenced-by-count":11,"title":["Application of xenogeneic anti\u2010canine distemper virus antibodies in treatment of canine distemper puppies"],"prefix":"10.1111","volume":"57","author":[{"given":"P. C.","family":"Liu","sequence":"first","affiliation":[{"name":"Graduate Institute of Veterinary Medicine National Taiwan University  10617 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Clinical Sciences National Taiwan University  10617 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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