{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:19:43Z","timestamp":1790039983412,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T00:00:00Z","timestamp":1491609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>An 11\u2010month\u2010old Border collie presented collapsed and continued to deteriorate rapidly despite supportive treatment. The dog had a history of failure to thrive and recurring respiratory infection. Laboratory abnormalities included neutrophilic leucocytosis, Heinz body anaemia, hyperammonaemia, hyperbilirubinaemia, proteinuria and hypocobalaminaemia. Post\u2010mortem examination revealed multi\u2010focal necrosis within the heart, kidneys, pancreas, liver, meninges and cerebral cortex. Fungal hyphae in lesions were identified as<jats:italic>Scedosporium prolificans<\/jats:italic>following culture. Subsequent genotyping confirmed that the dog carried the<jats:styled-content style=\"fixed-case\">CUBN<\/jats:styled-content>:c.<jats:styled-content style=\"fixed-case\">8392delC<\/jats:styled-content>mutation in a homozygous state, verifying hereditary cobalamin deficiency (a.k.a. Imerslund\u2010Gr\u00e4sbeck syndrome). Cobalamin deficiency may have been a predisposing factor for the development of systemic fungal infection in this dog.<\/jats:p>","DOI":"10.1111\/jsap.12678","type":"journal-article","created":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T14:42:46Z","timestamp":1491662566000},"page":"253-256","source":"Crossref","is-referenced-by-count":11,"title":["Systemic<i>Scedosporium prolificans<\/i>infection in an 11\u2010month\u2010old Border collie with cobalamin deficiency secondary to selective cobalamin malabsorption (canine Imerslund\u2010Gr\u00e4sbeck syndrome)"],"prefix":"10.1111","volume":"59","author":[{"given":"K.","family":"Erles","sequence":"first","affiliation":[{"name":"Department of Pathology and Pathogen Biology The Royal Veterinary College Hatfield AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mugford","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services The Royal Veterinary College Hatfield AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Barfield","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services The Royal Veterinary College Hatfield AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Leeb","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Vetsuisse Faculty University of Berne 3012 Berne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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