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Routine blood analysis revealed only mild abnormalities and<jats:styled-content style=\"fixed-case\">FeLV<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">FIV<\/jats:styled-content>tests were negative. Both popliteal lymph nodes were aspirated and cytology was consistent with reactive lymph node hyperplasia.<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>for antigen receptor rearrangement testing diagnosed a polyclonal cell population. In the absence of another cause, lymphadenomegaly was attributed to an adverse drug reaction and phenobarbital was discontinued. The cat's condition improved and lymph node size normalised over the next 10 days. 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