{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:04:01Z","timestamp":1775246641171,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to determine whether intra\u2010aural administration of aqueous solutions of marbofloxacin, gentamicin, tobramycin and ticarcillin (used off\u2010licence) was associated with changes in hearing as measured by brainstem auditory evoked responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Dogs diagnosed with otitis media (n=37) underwent brainstem auditory evoked response testing and then were treated for their ear disease. First, the external ear canal and middle ear were flushed with sterile saline followed by EDTA tris with 0\u00b715% chlorhexidine. Then, a combination of aqueous antibiotic mixed with an aqueous solution of EDTA tris was instilled into the middle ear. Follow\u2010up examinations were undertaken for each dog, and treatment was continued until there were no detected infectious organisms or inflammatory infiltrate. Brainstem auditory evoked response testing was repeated after resolution of the infection and discontinuation of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Brainstem auditory evoked responses in dogs treated with aqueous solutions of marbofloxacin or gentamicin remained unchanged or improved after therapy of otitis media but were impaired in dogs treated with ticarcillin or tobramycin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>If off\u2010licence use of topical antibiotics is deemed necessary in cases of otitis media, aqueous solutions of marbofloxacin and gentamicin appear to be less ototoxic than aqueous solutions of ticarcillin or tobramycin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12711","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T14:16:09Z","timestamp":1500387369000},"page":"10-15","source":"Crossref","is-referenced-by-count":17,"title":["Brainstem auditory evoked responses in 37 dogs with otitis media before and after topical therapy"],"prefix":"10.1111","volume":"59","author":[{"given":"S.","family":"Paterson","sequence":"first","affiliation":[{"name":"Department of Dermatology Rutland House Veterinary Hospital, Abbotsfield Road St Helens Merseyside WA9 4HU UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880040050009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197608000-00009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/134.Supplement_1.S200"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900100031003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1986.9694018"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.10.007"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215115002509"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1201\/b16788","volume-title":"Otitis Media Otitis Externa: An Essential Guide to Diagnosis and Treatment","author":"Harvey R. 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