{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:37:55Z","timestamp":1790714275848,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the CT findings in a population of dogs with multi\u2010centric lymphoma that involved the spleen and liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Clinical records between January 2008 and June 2015 were reviewed. Thoracic and abdominal CT examinations of patients diagnosed with multi\u2010centric lymphoma were evaluated by a board\u2010certified radiologist. A diagnosis of multi\u2010centric lymphoma with splenic and hepatic involvement was based upon cytological identification and immunophenotyping of neoplastic lymphocytes in cellular samples harvested from a peripheral lymph node, the spleen and the liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve dogs were included in this study, of which 11 had B\u2010cell lymphoma; immunophenotyping was inconclusive in one dog. The spleen appeared normal in seven dogs and nodules were identified in five dogs. Splenic nodules were hypoattenuating in four of five dogs and isoattenuating in one of five. After contrast administration, three of five appeared hypoattenuating and two of five isoattenuating. The liver appeared normal in 10 dogs and hepatic nodules were identified in two dogs. All hepatic nodules were isoattenuating before contrast and hypoattenuating following contrast administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The CT appearance of the spleen and liver was normal in the majority of dogs with multi\u2010centric lymphoma. Fine needle aspiration of the spleen and liver is recommended when using CT to stage dogs with multi\u2010centric lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12714","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T10:12:44Z","timestamp":1501582364000},"page":"622-628","source":"Crossref","is-referenced-by-count":15,"title":["Computed tomographic findings in 12 cases of canine multi\u2010centric lymphoma with splenic and hepatic involvement"],"prefix":"10.1111","volume":"58","author":[{"given":"I. D.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Queen Mother Hospital for Animals Royal Veterinary College Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Queen Mother Hospital for Animals Royal Veterinary College Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lara\u2010Garcia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Queen Mother Hospital for Animals Royal Veterinary College Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathogen Biology Royal Veterinary College Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mantis","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Queen Mother Hospital for Animals Royal Veterinary College Hatfield Hertfordshire AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2006.00192.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12075"},{"key":"e_1_2_5_4_1","first-page":"535","volume-title":"Miller's Anatomy of the Dog","author":"Bezuidenhout A. L.","year":"2013"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1997.tb02989.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1991.tb00112.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01725.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01808.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2004.04054.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12117"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-5-556"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1740-8261.2011.01917.x","article-title":"CT characteristics of primary hepatic mass lesions in dogs","volume":"53","author":"Fukoshima K.","year":"2012","journal-title":"Veterinary Radiology and Ultrasound"},{"key":"e_1_2_5_13_1","first-page":"69","volume-title":"Textbook of Review of Radiologic Physics","author":"Huda W.","year":"2010"},{"key":"e_1_2_5_14_1","first-page":"163","volume-title":"Textbook of Review of Radiologic Physics","author":"Huda W.","year":"2010"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12336"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12099"},{"key":"e_1_2_5_17_1","first-page":"487","article-title":"Ultrasonographic findings in hepatic and splenic lymphosarcoma in dogs and cats","volume":"32","author":"Lamb C. R.","year":"1991","journal-title":"Veterinary Radiology and Ultrasound"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0133.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12127"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1984.tb02137.x"},{"key":"e_1_2_5_21_1","unstructured":"Owen L. N.(1980) TNM Classification of Tumours in Domestic Animals. Geneva Switzerland; World Health Organization. pp46\u201047"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01872.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6132"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00200.x"},{"key":"e_1_2_5_25_1","first-page":"608","volume-title":"Textbook of Small Animal Clinical Oncology","author":"Vail D. M.","year":"2013"},{"key":"e_1_2_5_26_1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.2460\/javma.1988.193.12.1565","article-title":"Ultrasonographic features of splenic lymphosarcoma in dogs: 12 cases (1980\u20101986)","volume":"193","author":"Wrigley R. H.","year":"1988","journal-title":"Journal of the American Veterinary Medical Association"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsap.12714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.12714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T19:34:18Z","timestamp":1750793658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.12714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/jsap.12714"],"URL":"https:\/\/doi.org\/10.1111\/jsap.12714","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}