{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:20:13Z","timestamp":1790029213430,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To report clinical, laboratory and diagnostic imaging features and prognostic factors in dogs with leptospirosis from North\u2010East Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records of dogs diagnosed with leptospirosis from 2006 to 2013 were evaluated retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 99 dogs. At initial presentation, the most common clinical signs were lethargy (96%), anorexia (88%), vomiting (85%), painful abdomen (39%), diarrhoea (38%), oliguria (27%) and tachypnoea (26%). Abnormal laboratory findings included anaemia (63%), thrombocytopenia (63%), leucocytosis (57%), increase of plasma urea (84%) and creatinine concentrations (81%), increased liver enzyme activities (80%), hyperbilirubinaemia (69%), hyperphosphataemia (67%), hyponatraemia (64%), hypoalbuminaemia (55%) and hypokalaemia (29%). Radiological pulmonary changes were detected in 57% of the dogs initially or during the course of disease. Severe dyspnoea, oliguria, azotaemia, hyperbilirubinaemia and severe radiological pulmonary changes were more often found in dogs that did not survive. There was renal, hepatic and pulmonary involvement in 95, 92 and 58% of the dogs, respectively, and multi\u2010organ lesions in 98 dogs (98%); 32 dogs died or were euthanased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several clinical and laboratory abnormalities were associated with a negative outcome; severe lung involvement was specifically associated with high mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12718","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T08:22:52Z","timestamp":1502698972000},"page":"582-588","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of clinical, laboratory, imaging findings and outcome in 99 dogs with leptospirosis"],"prefix":"10.1111","volume":"58","author":[{"given":"S.","family":"Kn\u00f6pfler","sequence":"first","affiliation":[{"name":"Clinic for Small Animals Freie Universit\u00e4t Berlin, Oertzenweg 19b D\u201014163 Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mayer\u2010Scholl","sequence":"additional","affiliation":[{"name":"Federal Institute for Risk AssessmentDiedersdorfer Weg 1, D\u201012277 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Luge","sequence":"additional","affiliation":[{"name":"Federal Institute for Risk AssessmentDiedersdorfer Weg 1, D\u201012277 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Klopfleisch","sequence":"additional","affiliation":[{"name":"Institute for Veterinary Pathology Freie Universit\u00e4t Berlin, Robert\u2010von\u2010Ostertag\u2010Str. 15, D\u201014163 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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