{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T01:42:50Z","timestamp":1776390170299,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"American Humane Association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate prevalence of exposure to environmental tobacco smoke and other environmental toxins in dogs with primary lung tumours and to analyse association between exposure and lung tumour development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this case\u2013control study, an owner survey was developed to collect data on patient characteristics, general health care and environmental exposures. Dogs diagnosed with primary lung carcinomas formed the Case group. Dogs diagnosed with mast cell tumours served as Control Group 1 and dogs diagnosed with neurologic disease served as Control Group 2. Associations between diagnosis of primary lung tumour and patient and environmental exposure variables were analysed using bivariate and multivariate statistical methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1178 owner surveys were mailed and 470 surveys were returned and included in statistical analysis, including 135 Cases, 169 dogs in Control Group 1 and 166 dogs in Control Group 2. An association between exposure to second\u2010hand smoke and prevalence of primary lung cancer was not identified in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Second\u2010hand smoke is associated with primary lung cancer in people but a definitive association has not been found in dogs. The results of this study suggest that tobacco smoke exposure may not be associated with primary lung cancer development in dogs but study limitations may have precluded detection of an association.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12778","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T06:18:42Z","timestamp":1510640322000},"page":"343-349","source":"Crossref","is-referenced-by-count":22,"title":["Association between environmental factors including second\u2010hand smoke and primary lung cancer in dogs"],"prefix":"10.1111","volume":"59","author":[{"given":"A.","family":"Zierenberg\u2010Ripoll","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine University of California Davis California 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Pollard","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgical and Radiological Sciences University of California Davis California 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of California Davis California 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Allstadt","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Tennessee Knoxville Tennessee 37996 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. E.","family":"Barrett","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California Davis California 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Gillem","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Tennessee Knoxville Tennessee 37996 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A.","family":"Skorupski","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgical and Radiological Sciences University of California Davis California 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"29","article-title":"Current cigarette smoking among adults\u2014United States, 2005\u20102012. Centers for Disease Control and Prevention","volume":"63","author":"Agaku I. 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