{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:56:26Z","timestamp":1782816986898,"version":"3.54.5"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the clinical signs, laboratory results, therapy and course of disease in dogs with canine granulocytic anaplasmosis in which co\u2010infections had been excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of dogs naturally infected with<jats:italic>Anaplasma phagocytophilum<\/jats:italic>were retrospectively evaluated with regard to clinical signs and laboratory abnormalities at the time of presentation, therapy and course of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine hundred and seventy\u2010four dogs with clinical signs suspicious for canine granulocytic anaplasmosis were tested for<jats:italic>A. phagocytophilum<\/jats:italic>DNA by modified real\u2010time PCR; 72 dogs had a positive result. Nine of the positive dogs were excluded from further evaluation due to other diseases or lack of data. The most common clinical signs in the 63<jats:italic>A. phagocytophilum<\/jats:italic>\u2010positive dogs included in the study were lethargy and reduced activity (83%), fever (67%) and inappetence (63%). Thrombocytopenia was the most common laboratory abnormality (86%), followed by increased liver enzyme activities and hyperbilirubinaemia (77%), anaemia (70%), hypoalbuminaemia (62%) and leucocytosis (27%). Of 36 thrombocytopenic dogs tested for platelet\u2010bound antibodies, 44% were positive. Of the 63 infected dogs, 59 (97%) recovered, two dogs died (epileptic seizures and immune\u2010mediated haemolytic anaemia) and two were lost to follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>In areas where it is endemic, canine granulocytic anaplasmosis should be considered as a potential cause of acute nonspecific clinical signs or immune\u2010mediated disease if tick exposure cannot be excluded<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12787","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T10:26:44Z","timestamp":1511519204000},"page":"112-120","source":"Crossref","is-referenced-by-count":45,"title":["Granulocytic anaplasmosis in 63 dogs: clinical signs, laboratory results, therapy and course of disease"],"prefix":"10.1111","volume":"59","author":[{"given":"A.","family":"Chirek","sequence":"first","affiliation":[{"name":"Clinic for Small Animals, Faculty of Veterinary Medicine Freie Universit\u00e4t Berlin 14163 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Silaghi","sequence":"additional","affiliation":[{"name":"Comparative Tropical Medicine and Parasitoloy Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen 80802 Munich Germany"},{"name":"National Center of Vector Entomology, Institute of Parasitology University of Zurich 8057 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Pfister","sequence":"additional","affiliation":[{"name":"Comparative Tropical Medicine and Parasitoloy Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen 80802 Munich Germany"},{"name":"Parasite Consulting GmbH CH\u20103006 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kohn","sequence":"additional","affiliation":[{"name":"Clinic for Small Animals, Faculty of Veterinary Medicine Freie Universit\u00e4t Berlin 14163 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.5326\/0410323"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1374.042"},{"key":"e_1_2_5_4_1","first-page":"342","article-title":"Seroprevalence of Anaplasma phagocytophilum infection in dogs in Germany","volume":"119","author":"Barutzki D.","year":"2006","journal-title":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1128\/JCM.37.11.3448-3451.1999","article-title":"Prevalence of Borrelia burgdorferi and granulocytic and monocytic ehrlichiae in Ixodes ricinus ticks from southern Germany","volume":"37","author":"Baumgarten B. 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