{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T18:36:10Z","timestamp":1785090970059,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the histopathological frequency of feline hepatobiliary diseases in the UK and to identify breed, age and gender predispositions to developing individual diseases.\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Histopathology results from 1452 feline liver biopsies were assessed. A control population of microchipped cats was used for breed comparison. Data were retrospectively categorised into hepatobiliary diseases according to World Small Animal Veterinary Association standards. Odds ratios and 95% confidence intervals were calculated to determine breed predispositions to the 10 most frequent diseases. Gender and age distributions were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most frequent diseases based on histopathology were neutrophilic cholangitis (20\u00b75%), reactive hepatitis (20\u00b74%), reversible hepatocellular injury (8\u00b74%), lymphocytic cholangitis (6\u00b78%), biliary cysts (5\u00b77%), acute hepatitis (5\u00b76%), haematopoietic neoplasia (5\u00b76%), hepatocellular neoplasia (4\u00b79%), congenital portosystemic shunt (3\u00b78%) and cholangiocellular neoplasia (3\u00b71%). Some previously unreported breed and age predispositions were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>This is the first study to document the histopathological frequency of hepatobiliary diseases in a large cohort of cats in the UK, as well as novel breed and age predispositions. These data may help increase the index of suspicion of a particular disease in the absence of a biopsy\u2010confirmed diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12810","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T16:23:17Z","timestamp":1515601397000},"page":"404-410","source":"Crossref","is-referenced-by-count":26,"title":["Histopathological frequency of feline hepatobiliary disease in the UK"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9387-8258","authenticated-orcid":false,"given":"W. A.","family":"Bayton","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Westgarth","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Science The University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Scase","sequence":"additional","affiliation":[{"name":"Bridge Pathology LTD  Bristol, BS7 0BJ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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