{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:22:44Z","timestamp":1772270564194,"version":"3.50.1"},"reference-count":81,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Diverse drugs with presumed cytoprotective effect have been used therapeutically in small animal veterinary practice for various gastro\u2010intestinal conditions such as oesophagitis, gastric ulceration, gastritis or chronic gastro\u2010enteropathies. Their efficacy has been doubted in human medicine, raising similar questions in the veterinary field. The aim of this review was to assess the current evidence on the efficacy and safety of these drugs in dogs and cats. Through a systematic review of the literature, we identified 37 articles on the use of misoprostol, sucralfate and other gastroprotectants in dogs and cats. There was evidence to support use of misoprostol in the prevention of aspirin\u2010induced gastroduodenal mucosal injury in dogs, and for use of sucralfate in the prevention of acid\u2010induced oesophagitis in cats. However, the overall quality of evidence supporting the use of these drugs in small animal patients was poor. In contrast, there was evidence of important adverse effects, especially drug interaction and gastro\u2010intestinal signs. We therefore recommend prescribing these drugs with caution until further well\u2010conducted studies reveal a useful gastroprotectant effect.<\/jats:p>","DOI":"10.1111\/jsap.12867","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T04:48:40Z","timestamp":1530766120000},"page":"587-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gastroprotectants in small animal veterinary practice \u2013 a review of the evidence. 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