{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:06:24Z","timestamp":1769090784843,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the outcome of dogs with central nervous system lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A multi\u2010center, retrospective, observational study was conducted by reviewing medical records of 18 cases of central nervous system lymphoma from seven institutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diagnosis of lymphoma was made through cerebrospinal fluid analysis, histopathology, flow cytometry of the cerebrospinal fluid, and cytology of cerebrospinal fluid, lymph node or spleen with correlated imaging. A total of 15 of 18 dogs received specific treatment other than prednisone. Three dogs underwent chemotherapy and radiation therapy after surgical decompression, five dogs underwent chemotherapy, two dogs underwent radiation therapy after surgical decompression, three dogs underwent chemotherapy after surgical decompression and two dogs underwent radiation therapy and chemotherapy. Only one dog received prednisone, and two dogs did not receive any treatment. Overall, the median survival time was 171\u2009days (range 1 to 1942\u2009days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Dogs receiving any type of treatment for central nervous system lymphoma lived longer than cases described in previous historical reports. Further studies are needed to elucidate the importance of specific treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12868","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:39:07Z","timestamp":1531993147000},"page":"547-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Central nervous system lymphoma in 18 dogs (2001 to 2015)"],"prefix":"10.1111","volume":"59","author":[{"given":"M. K.","family":"LaRue","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary MedicineAuburn University Auburn Alabama 36849 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary MedicineAuburn University Auburn Alabama 36849 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Back","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary MedicineAuburn University Auburn Alabama 36849 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. E.","family":"Lindley","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary MedicineAuburn University Auburn Alabama 36849 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. L.","family":"Boudreaux","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary MedicineLouisiana State University Baton Rouge Louisiana 70803 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. T.","family":"Almond","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary MedicineAuburn University Auburn Alabama 36849 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Shores","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary MedicineMississippi State University Mississippi State Mississippi 39762 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. R.","family":"Brawner","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary MedicineAuburn University Auburn Alabama 36849 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. N.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary MedicineAuburn University Auburn Alabama 36849 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12340"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(83)90323-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(84)90007-0"},{"key":"e_1_2_5_5_1","volume-title":"Cancer Chemotherapy and Biotherapy: Principles and Practice","author":"Chabner B. A.","year":"2011"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2460\/javma.1984.184.07.809","article-title":"Central nervous system lymphosarcoma in the dog","volume":"184","author":"Couto C.","year":"1984","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2012.02.009"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12109"},{"key":"e_1_2_5_9_1","first-page":"55","article-title":"Intraspinal tumors in the dog","volume":"5","author":"Gilmore D.","year":"1983","journal-title":"Compendium on Continuing Education for the Practicing Veterinarian"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815626576"},{"key":"e_1_2_5_11_1","first-page":"559","article-title":"Primary central nervous system B\u2010cell lymphoma in a young dog","volume":"53","author":"Kim N.\u2010H.","year":"2012","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-3390-7"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.719"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2017"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01872.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90009-7"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2460\/javma.1982.181.01.50","article-title":"Neurologic diseases associated with lymphosarcoma in ten dogs","volume":"181","author":"Rosin A.","year":"1982","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb01140.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985811419531"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.11.075"},{"key":"e_1_2_5_21_1","first-page":"778","article-title":"Central nervous system relapses in 3 dogs with B\u2010cell lymphoma","volume":"52","author":"Seo K.\u2010W.","year":"2011","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2014.06.011"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985816658101"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1939-1676.2006.tb02913.x","article-title":"Canine intracranial primary neoplasia: 173 cases (1986\u20102003)","volume":"20","author":"Snyder J. M.","year":"2006","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"e_1_2_5_25_1","first-page":"519","article-title":"Comparative imaging of spinal extradural lymphoma in a Bordeaux dog","volume":"51","author":"Veraa S.","year":"2010","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.12.020"},{"key":"e_1_2_5_27_1","volume-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Withrow S. J.","year":"2013"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjsap.12868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.12868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T22:04:26Z","timestamp":1751753066000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.12868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,19]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/jsap.12868"],"URL":"https:\/\/doi.org\/10.1111\/jsap.12868","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,19]]},"assertion":[{"value":"2017-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}