{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:52:08Z","timestamp":1784130728528,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterise the signalment, clinical presentation and therapy of pemphigus foliaceus in cats treated by primary care practitioners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Retrospective evaluation of patient and treatment factors with the following case outcomes: remission (achieving remission, time to remission), treatment\u2010related adverse effects (number, severity) and final disease outcome (medical control, cure, death or euthanasia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were obtained from 48 cats with biopsy\u2010confirmed pemphigus foliaceus managed by practitioners from six countries and 47 hospitals. Clinicians prescribed oral prednisolone most commonly for immunosuppression (median dose 2\u00b72\u00a0mg\/kg\/day). Disease remission information was available in 40 cats; 90% achieved disease remission, which did not appear related to the doses of oral glucocorticoid administered in this study. Disease relapse occurred in 29 (73%) cats after achieving remission, necessitating medication adjustments. Severe treatment\u2010related adverse effects occurred in eight cases, including both cats treated with long\u2010acting injectable glucocorticoids. Of 31 cats treated with glucocorticoid monotherapy, 27 achieved remission, as did eight of 11 ciclosporin <jats:italic>plus<\/jats:italic> glucocorticoid\u2010treated cats. Eleven cats experienced adverse effects: five receiving ciclosporin <jats:italic>plus<\/jats:italic> glucocorticoid and six receiving glucocorticoid monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Pemphigus foliaceus remission with treatment is highly likely in cats but relapse is common, necessitating close monitoring and individualised therapy modifications. Clinicians should focus on the judicious use of glucocorticoids to minimise treatment\u2010related adverse effects, such as avoiding injectable glucocorticoids, combining glucocorticoids with steroid\u2010sparing medications, and regularly rechecking patients to adjust drug dosages in response to disease status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12869","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T05:58:41Z","timestamp":1530511121000},"page":"553-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Feline pemphigus foliaceus in non\u2010specialist veterinary practice: a retrospective analysis"],"prefix":"10.1111","volume":"59","author":[{"given":"K.","family":"Coyner","sequence":"first","affiliation":[{"name":"Dermatology Clinic for Animals Lacey WA 98516 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tater","sequence":"additional","affiliation":[{"name":"Veterinary Information Network  Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rishniw","sequence":"additional","affiliation":[{"name":"Veterinary Information Network  Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2013.02.004"},{"key":"e_1_2_5_3_1","first-page":"152","volume-title":"Advances in Veterinary Dermatology","author":"Graham\u2010Mize C. 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