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Signalment, presence or absence of hyperadrenocorticism, aetiology of hyperadrenocorticism (if described), frequency of select comorbidities and causes of death were evaluated in dogs with and without hyperadrenocorticism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hyperadrenocorticism was more frequent in females. Neutering was associated with a minor, but significant, increase in the odds of hyperadrenocorticism. Hyperadrenocorticism was the presumed cause of death of 393 (25\u22199%) of affected dogs. When aetiology was specified (527 dogs, corresponding to 34\u22197% of the cases), pituitary\u2010dependent hyperadrenocorticism [387 (73\u22194%) out of 527 dogs] was more common than functional adrenocortical tumour [136 (25\u22198%) out of 527 dogs). Hyperadrenocorticism was over\u2010represented in certain expected (miniature poodle, dachshund) and unexpected (Irish setter, bassett hound) breeds compared with the population at large. Of the select comorbidities investigated, dogs with hyperadrenocorticism were at increased risk for concurrent diabetes mellitus, urinary tract infection, urolithiasis, hypertension, gall bladder mucocoele and thromboembolic disease compared with dogs without hyperadrenocorticism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Hyperadrenocorticism is significantly associated with certain comorbid conditions but is not a major cause of mortality in affected dogs. Documented patterns now provide targets for prospective clinical research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12904","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T05:34:17Z","timestamp":1532410457000},"page":"681-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Canine hyperadrenocorticism associations with signalment, selected comorbidities and mortality within North American veterinary teaching hospitals"],"prefix":"10.1111","volume":"59","author":[{"given":"J. M.","family":"Hoffman","sequence":"first","affiliation":[{"name":"Department of Genetics University of Georgia Athens Georgia 30602 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-4645","authenticated-orcid":false,"given":"B. 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