{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:45:46Z","timestamp":1762033546119},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the potency and reproducibility of milbemycin oxime when compounded as an aqueous suspension (20\u2009mg\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Preparation choice reflected current prescribing practices. Samples were acquired by prescription from two national veterinary compounding pharmacies at three time points. Two different storage conditions were evaluated and sampled at four time points from the order date (day 7, 14, 21 and 28). Milbemycin oxime recovery was performed by solid\u2010phase extraction and concentration strength measured <jats:italic>via<\/jats:italic> high\u2010performance liquid chromatography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average concentration on day 7 for Pharmacy A samples was 16.29\u2009mg\/mL [confidence interval (CI): 15.66 to 16.92] with a coefficient of variation (CV)\u2009=\u200911%, while for Pharmacy B it was 20.46\u2009mg\/mL (CI: 19.83 to 21.08) with CV\u2009=\u200922%. The mean decrease in concentration over 28\u2009days for Pharmacy A was 22% (CI: 9% to 34%) while Pharmacy B was 18% (CI: 2% to 35%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The compounded milbemycin oxime suspensions evaluated in this study deviated by more than 10% from their labelled strength in five of the six lots. Clinical efficacy of compounded milbemycin oxime suspensions remains unknown and the use of these products should be discouraged at this time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12907","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T05:33:22Z","timestamp":1531373602000},"page":"27-31","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of compounded aqueous milbemycin oxime: issues with formulation potency and reproducibility"],"prefix":"10.1111","volume":"60","author":[{"given":"Z. N.","family":"Cochrane","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Iowa State University, College of Veterinary Medicine Ames IA 50011 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Iowa State University, College of Veterinary Medicine Ames IA 50011 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Viall","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology Iowa State University, College of Veterinary Medicine Ames IA 50011 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Schrunk","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory Iowa State University, College of Veterinary Medicine Ames IA 50011 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"(Hans) Coetzee","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology Kansas State University, College of Veterinary Medicine Manhattan KS 66505 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"AllenL.V. BassaniG ElderE et al.(2014) Strength and stability testing for compounded preparations.International Journal of Pharmaceutical Compounding.www.usp.org\/sites\/default\/...\/strength-stability-testing-compounded-preparations. Accessed May 14 2016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00725.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2006.07.003"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5763"},{"key":"e_1_2_5_6_1","unstructured":"CPG. 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