{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:35:56Z","timestamp":1791995756123,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the incidence of relapse after discharge from the hospital in dogs with a diagnosis of presumed primary immune\u2010mediated thrombocytopenia, risk factors associated with relapse and whether or not indefinite use of immunosuppressive medication influences risk of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records from August 2007 through July 2016 were reviewed to identify dogs with a diagnosis of presumed primary immune\u2010mediated thrombocytopenia. Data collection included signalment, initial diagnostic tests, treatment, incidence of relapse, survival duration and follow\u2010up testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 45 dogs were diagnosed, treated and monitored for at least one\u00a0year for presumed primary immune\u2010mediated thrombocytopenia. 89\u22196% of patients survived to discharge and 31% of those experienced a relapse following discharge. The median time from diagnosis to relapse was 79\u2009days. Of dogs that experienced a relapse, 50% had at least one further relapse. There was no difference in age, body weight, gender, breed, platelet count at presentation, nadir packed cell volume during hospitalisation, incidence of melaena or initial treatment between the relapsing and non\u2010relapsing groups. In the relapsing group, time to platelet recovery was significantly longer and these patients were more likely to have received a blood transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>This study does not provide evidence to support the use of long\u2010term immunosuppressive medications to prevent relapse. However, the data suggest that patients with more severe disease at the time of diagnosis or that have already experienced a relapse should be monitored more closely.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12912","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T14:33:35Z","timestamp":1534170815000},"page":"674-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Long\u2010term outcome of primary immune\u2010mediated thrombocytopenia in dogs"],"prefix":"10.1111","volume":"59","author":[{"given":"K.","family":"Simpson","sequence":"first","affiliation":[{"name":"Veterinary Specialty and Emergency Center Philadelphia Pennsylvania 19056 USA"},{"name":"Premier Veterinary Group by ETHOS Chicago Illinois 60618 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Veterinary Specialty and Emergency Center Philadelphia Pennsylvania 19056 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Klag","sequence":"additional","affiliation":[{"name":"Veterinary Specialty and Emergency Center Philadelphia Pennsylvania 19056 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12066"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0358.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.164.21.647"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12621"},{"key":"e_1_2_5_6_1","first-page":"245","article-title":"Immune\u2010mediated hemolytic anemia and thrombocytopenia in the dog: a retrospective study of 55 cases diagnosed from 1969 through 1983 at the Western College of Veterinary Medicine","volume":"26","author":"Jackson M. 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