{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:52Z","timestamp":1787015692869,"version":"build-2736575974"},"reference-count":7,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology, Japan","doi-asserted-by":"crossref","award":["17H05043"],"award-info":[{"award-number":["17H05043"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,12]]},"abstract":"\n Objectives<\/jats:title>\n To investigate the clinical characteristics of feline acute lymphoblastic leukaemia patients diagnosed according to the recent diagnostic criteria for the equivalent canine condition.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n The medical records of six cats diagnosed with acute lymphoblastic leukaemia were retrospectively reviewed to extract data on clinicopathological characteristics and outcomes. The lymphoid origin of the tumour cells was confirmed by polymerase chain reaction for antigen receptor gene rearrangement, flow cytometry or immunohistochemistry.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Non\u2010specific clinical signs such as lethargy and anorexia were common, and anaemia and thrombocytopenia were also commonly identified. Leucocytosis was observed in four cats and leucopenia was observed in two; the number of lymphoblasts in the peripheral blood samples varied among the cases. Lymphoblasts originated from B\u2010cell lineage in four cats and T\u2010cell lineage in one, and those of another cat were positive for both B\u2010cell marker CD21 and T\u2010cell marker CD8. Five of the six cats were treated with cytotoxic chemotherapy, and a partial response was obtained in two. The median overall survival was 55\u2009days (range: 1 to 115).<\/jats:p>\n <\/jats:sec>\n \n Clinical Significance<\/jats:title>\n Acute lymphoblastic leukaemia should be considered if lymphoblasts are observed in peripheral blood, even if their number is small. The prognosis for cats that have acute lymphoblastic leukaemia is as poor as that for dogs, and further studies are needed to develop effective treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jsap.12917","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T07:10:16Z","timestamp":1535699416000},"page":"742-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical and clinicopathological characteristics of acute lymphoblastic leukaemia in six cats"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-6218","authenticated-orcid":false,"given":"H.","family":"Tomiyasu","sequence":"first","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences The University of Tokyo 1\u20101\u20101\u00a0Yayoi, Bunkyo\u2010ku, Tokyo 113\u20108657 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Doi","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center, Graduate School of Agricultural and Life Sciences The University of Tokyo 1\u20101\u20101 Yayoi, Bunkyo\u2010ku, Tokyo 113\u20108657 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. K.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences The University of Tokyo 1\u20101\u20101 Yayoi, Bunkyo\u2010ku, Tokyo 113\u20108657 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Goto\u2010Koshino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences The University of Tokyo 1\u20101\u20101\u00a0Yayoi, Bunkyo\u2010ku, Tokyo 113\u20108657 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ohmi","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center, Graduate School of Agricultural and Life Sciences The University of Tokyo 1\u20101\u20101 Yayoi, Bunkyo\u2010ku, Tokyo 113\u20108657 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences The University of Tokyo 1\u20101\u20101\u00a0Yayoi, Bunkyo\u2010ku, Tokyo 113\u20108657 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences The University of Tokyo 1\u20101\u20101\u00a0Yayoi, Bunkyo\u2010ku, Tokyo 113\u20108657 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00189.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12251"},{"key":"e_1_2_5_4_1","first-page":"166","article-title":"Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone: II. Treatment of Cats","volume":"19","author":"Cotter S. M.","year":"1983","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2460\/javma.1987.191.06.707","article-title":"Low\u2010dose cytosine arabinoside\u2010induced remission of lymphoblastic leukemia in a cat","volume":"191","author":"Helfand S. 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