{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:19:47Z","timestamp":1777652387661,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare two minimally invasive enilconazole infusion protocols for the treatment of canine sinonasal aspergillosis and evaluate the importance of complete endoscopic debridement in determining first treatment success rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Data for 48 dogs with confirmed sinonasal aspergillosis treated with endoscopic debridement followed by per\u2010endoscopic enilconazole infusion were collected. Twenty\u2010four dogs were treated according to the previously published 1\u2010hour infusion protocol and 24 dogs underwent a simplified 15\u2010minute infusion protocol. Completeness of debridement, evaluated as partial or complete at the end of the procedure and outcome after one or several treatments were assessed in all dogs. Multi\u2010variable analysis was performed to derive odds ratios and 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median duration of the simplified protocol \u2013 92\u22193\u2009minutes (range 40 to 140) \u2013 was substantially shorter than the duration of the previous protocol \u2013 201\u22193\u2009minutes (range 120 to 265). First treatment success rates were 58 and 62\u22195% for the previous and simplified protocol, respectively. Overall treatment success rate was similar in both groups (96%). Complete debridement was associated with an improved first treatment success rate compared to partial debridement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The simplified protocol is a valid alternative approach to the treatment of sinonasal aspergillosis. Completeness of endoscopic debridement before infusion is an important step for the success of treatment in canine sinonasal aspergillosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.12933","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T06:56:22Z","timestamp":1540536982000},"page":"777-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of two minimally invasive enilconazole perendoscopic infusion protocols for the treatment of canine sinonasal aspergillosis"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-9275","authenticated-orcid":false,"given":"E.","family":"Vangrinsven","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine University of Li\u00e8ge 4000 Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Girod","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine University of Li\u00e8ge 4000 Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine University of Li\u00e8ge 4000 Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Desquilbet","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics Unit, National Veterinary School of Alfort University of Paris\u2010Est 94704 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Clercx","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine University of Li\u00e8ge 4000 Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Billen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine University of Li\u00e8ge 4000 Li\u00e8ge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1035","volume-title":"Textbook of Veterinary Internal Medicine","author":"Billen F.","year":"2017"},{"key":"e_1_2_5_3_1","first-page":"164","article-title":"Efficacy of intrasinusal administration of bifonazole cream alone or in combination with enilconazole irrigation in canine sino\u2010nasal aspergillosis: 17 cases","volume":"51","author":"Billen F.","year":"2010","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.100041"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00154.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00153.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.151.10.298"},{"key":"e_1_2_5_8_1","unstructured":"Greci V. 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