{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:39:42Z","timestamp":1784360382810,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the outcome of endoscopic injection of two different bulking agents, glutaraldehyde cross\u2010linked collagen and dextranomer\/hyaluronic acid copolymer into the urethral submucosa in female dogs with urinary incontinence caused by urethral sphincter mechanism incompetence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Retrospective review of records and follow\u2010up communication with owners of dogs that received an endoscopically guided urethral bulking procedure. In each dog, either cross\u2010linked collagen (2007 to 2011) or dextranomer\/hyaluronic acid copolymer (2012 to 2015) was used. At least three injections were made in a circular arrangement in the midurethral region until the urethral lumen was closed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Complete questionnaires were available from 50 of 100 pet owners. The mean interval between the treatment and interview was 67 (range: 57 to 114) months in the cross\u2010linked collagen group and 19 (range: 2 to 48) months in the dextranomer\/hyaluronic acid copolymer group. The mean duration of continence was 45\u22198 months (range: 12 to 84 months) in the cross\u2010linked collagen group and 20\u22195 months (range: 12 to 48 months) in the dextranomer\/hyaluronic acid copolymer group. The success rate at 6 months or more after the procedure was 71% after the injection of cross\u2010linked collagen and 58% after injection of dextranomer\/hyaluronic acid copolymer. One minor complication (transient haematuria) occurred in one dog. There were no major complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Urethral injection of dextranomer\/hyaluronic acid copolymer in bitches with urethral sphincter mechanism incompetence is a useful alternative to cross\u2010linked collagen injection, which is no longer available in the European market. Dextranomer\/hyaluronic acid copolymer injection is a minimally invasive alternative to surgical procedures and has a low complication rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.12949","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T05:15:50Z","timestamp":1541135750000},"page":"96-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Retrospective analysis after endoscopic urethral injections of glutaraldehyde\u2010cross\u2010linked\u2010collagen or dextranomer\/hyaluronic acid copolymer in bitches with urinary incontinence"],"prefix":"10.1111","volume":"60","author":[{"given":"K.","family":"L\u00fcttmann","sequence":"first","affiliation":[{"name":"EVIDENSIA Tier\u00e4rztliche Klinik f\u00fcr Kleintiere Norderstedt GmbH 22850 Norderstedt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Merle","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Epidemiology and Biometry Freie Universit\u00e4t Berlin 14163 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Nickel","sequence":"additional","affiliation":[{"name":"EVIDENSIA Tier\u00e4rztliche Klinik f\u00fcr Kleintiere Norderstedt GmbH 22850 Norderstedt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06305.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.2460\/javma.1989.195.10.1369","article-title":"Treatment of urinary incontinence in dogs by endoscopic injection of Teflon","volume":"195","author":"Arnold S.","year":"1989","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1996.tb01951.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.226.73"},{"key":"e_1_2_5_6_1","unstructured":"Bradley C.G. 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