{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:11:24Z","timestamp":1770754284069,"version":"3.50.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of atorvastatin on haemostatic parameters as measured by prothrombin time, activated partial thromboplastin time and thromboelastography in apparently healthy dogs administered 2\u00a0mg\/kg orally once daily for 1\u00a0week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Prospective study of 20 apparently healthy client\u2010owned dogs at a small animal specialty hospital. Dogs had a baseline complete blood count, serum chemistry profile, fibrinogen, platelet count, prothrombin time, activated partial thromboplastin time and thromboelastography performed. Each dog was then administered approximately 2\u00a0mg\/kg of atorvastatin orally once daily for 1\u2009week, and the laboratory tests were repeated. Adverse effects attributed to atorvastatin were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 20 enrolled dogs completed the study. Dogs received a median dose of 2.06\u2009mg\/kg (range 1.94 to 2.44\u2009mg\/kg) atorvastatin once daily, which was associated with a significant increase in pulse rate, mean corpuscular haemoglobin concentration, albumin and a significant decrease in mean corpuscular volume, cholesterol and lipase values compared with baseline. On thromboelastography, there was a significant increase in maximum amplitude, G, coagulation index, amplitude at 30\u2009minutes, amplitude at 60\u00a0minutes and significant decrease in percentage of clot lysed at 30\u2009minutes and percentage of clot lysed at 60\u2009minutes values compared with baseline. Six dogs had a noticeable increase in appetite.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The results of this study suggest that atorvastatin may produce a procoagulant effect in dogs, although the clinical significance is unclear. Polyphagia was the most commonly reported adverse effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13005","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T06:18:47Z","timestamp":1556777927000},"page":"565-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of atorvastatin on haemostatic parameters in apparently healthy dogs"],"prefix":"10.1111","volume":"60","author":[{"given":"A.","family":"Bonaparte","sequence":"first","affiliation":[{"name":"VCA West Coast Specialty and Emergency Animal Hospital  Fountain Valley California 92708 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tansey","sequence":"additional","affiliation":[{"name":"Inland Valley Veterinary Specialists and Emergency Center  Upland California 91786 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Inland Valley Veterinary Specialists and Emergency Center  Upland California 91786 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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