{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:40:20Z","timestamp":1747186820447,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A1B03032499"],"award-info":[{"award-number":["2017R1D1A1B03032499"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To measure serum leptin concentration in dogs with pituitary\u2010dependent hyperadrenocorticism and varying degrees of cholestatic disease and determine whether serum levels differed between dogs with pituitary\u2010dependent hyperadrenocorticism and those with gall bladder mucocoele.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Client\u2010owned healthy dogs (n=20), dogs diagnosed with gall bladder mucocoele (n=20) and dogs diagnosed with pituitary\u2010dependent hyperadrenocorticism (n=60) were enrolled. Only dogs of normal body condition score were included. Dogs with pituitary\u2010dependent hyperadrenocorticism were divided into three groups according to the severity of cholestatic disease: normal gall bladder (n=20), cholestasis (n=20) and gall bladder mucocoele (n=20). Serum leptin levels were measured using sandwich enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum concentrations of leptin were similar between dogs with gall bladder mucocoele and those with pituitary\u2010dependent hyperadrenocorticism accompanied by gall bladder mucocoele; these concentrations were significantly higher than those in healthy control dogs. In dogs with pituitary\u2010dependent hyperadrenocorticism, circulating leptin concentration significantly increased with the severity of cholestasis: higher in the cholestasis group than the normal gall bladder group and higher in the gall bladder mucocoele group than the cholestasis group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Elevated circulating leptin concentration was associated with canine pituitary\u2010dependent hyperadrenocorticism and gall bladder mucocoele. Homeostatic imbalance of leptin concentration might be associated with severity of cholestatic disease in pituitary\u2010dependent hyperadrenocorticism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13044","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T13:53:21Z","timestamp":1562334801000},"page":"601-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship of serum leptin concentration with pituitary\u2010dependent hyperadrenocorticism and cholestatic disease in dogs"],"prefix":"10.1111","volume":"60","author":[{"given":"S.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University  Seoul 151\u2010742 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.\u2010K.","family":"Kweon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University  Seoul 151\u2010742 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-2036","authenticated-orcid":false,"given":"W. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University  Seoul 151\u2010742 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0766"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12192"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(83)80086-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2000.tb01489.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12270"},{"volume-title":"Textbook of Veterinary Internal Medicine","year":"2009","author":"Ettinger S. J.","key":"e_1_2_5_7_1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(01)00046-4"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.09.015"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.09-0367"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.64.349"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2006.06.002"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.78.2.223"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2015.16.3.333"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14608"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.10.019"},{"key":"e_1_2_5_17_1","first-page":"10","article-title":"Development and validation of a body condition score system for dogs","volume":"22","author":"Laflamme D.","year":"1997","journal-title":"Canine Practice"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979884"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2016.09.002"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14612"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187315"},{"key":"e_1_2_5_22_1","first-page":"557","article-title":"The use of diagnostic computerized tomography and radiation therapy in canine and feline hyperadrenocorticism","volume":"2","author":"Mauldin G.","year":"1990","journal-title":"Problems in Veterinary Medicine"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2009.00811.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2016.07.002"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.224.1615"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2009.10.008"},{"key":"e_1_2_5_27_1","first-page":"1299","article-title":"Plasma leptin levels in relation to body composition and body fat distribution in patients with Cushing's syndrome","volume":"110","author":"Robaczyk M.","year":"2003","journal-title":"Polskie Archiwum Medycyny Wewnetrznej"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01868.x"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.13044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsap.13044","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.13044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T23:19:39Z","timestamp":1694215179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.13044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,5]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/jsap.13044"],"URL":"https:\/\/doi.org\/10.1111\/jsap.13044","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"type":"print","value":"0022-4510"},{"type":"electronic","value":"1748-5827"}],"subject":[],"published":{"date-parts":[[2019,7,5]]},"assertion":[{"value":"2018-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}