{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:38:21Z","timestamp":1791819501581,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"TVM and Domes Pharma Laboratories"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the clinical and visual outcomes following intensive medical therapy for keratomalacia in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records were screened to identify dogs with corneal ulcers and keratomalacia. All patients were given the same topical treatment protocol with frequent administrations of tobramycin in combination with equine serum. Surgical treatment during the first 15\u2009days of follow\u2010up was considered as medical treatment failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report on 57 ulcers with keratomalacia from 53 dogs. Medical treatment was successful in 31 of 57 ulcers with a median healing time of 5\u2009days (range 2 to 15\u2009days). At 60\u2009days after epithelialisation, 14\/15 medically\u2010treated eyes were visual. In one case, corneal perforation was observed 1\u00a0month after healing and required surgical stabilisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Intensive medical therapy has the potential to achieve healing of some ulcers with keratomalacia. Surgical stabilisation in response to progression of stromal loss was required in less than half of the cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13118","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T12:25:27Z","timestamp":1581942327000},"page":"253-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Outcome of medical therapy for keratomalacia in dogs"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2508-2623","authenticated-orcid":false,"given":"A.","family":"Guyonnet","sequence":"first","affiliation":[{"name":"Unit\u00e9 d'Ophtalmologie, CHUVA Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort F\u201094700 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Desquilbet","sequence":"additional","affiliation":[{"name":"BioP\u00f4le, Unit\u00e9 de Biostatistique et d'\u00e9pid\u00e9miologie Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort F\u201094700 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Faure","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Ophtalmologie, CHUVA Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort F\u201094700 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8419-7669","authenticated-orcid":false,"given":"A.","family":"Bourguet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Ophtalmologie, CHUVA Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort F\u201094700 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Donzel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Ophtalmologie, CHUVA Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort F\u201094700 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chahory","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Ophtalmologie, CHUVA Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort F\u201094700 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"381","volume-title":"Veterinary Ophthalmology","author":"Clode A.","year":"2013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.76.11.989"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12193"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12085"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12325"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(79)90128-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3201"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3933"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00610.x"},{"key":"e_1_2_5_11_1","first-page":"976","volume-title":"Veterinary Ophthalmology","author":"Ledbetter E. 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