{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:28:41Z","timestamp":1792798121133,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CEVA Animal Health Ltd","id":[{"id":"https:\/\/ror.org\/05fxdte78","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Filavie Laboratories"},{"name":"Nigel and Frances Harcourt-Brown"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To report clinical features, gross\n                      <jats:italic>post mortem<\/jats:italic>\n                      and histopathological findings from an investigation into sudden or unexpected death in rabbits that was undertaken during an outbreak of rabbit haemorrhagic disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Using a standard protocol, veterinarians were invited to submit case histories and results of their\n                      <jats:italic>post mortem<\/jats:italic>\n                      examination of pet rabbits that died unexpectedly. Histopathological examination of heart, lungs, liver, spleen and kidney samples was collated with macroscopic appearance and clinical details.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hepatocellular necrosis, characteristic of rabbit haemorrhagic disease, was observed in 185 of 300 (62%) submissions, often accompanied by glomerular thrombosis and changes in other organs. Evidence of rabbit haemorrhagic disease was not apparent on histopathology in 113 of 300 (38%) rabbits. Gross\n                      <jats:italic>post mortem<\/jats:italic>\n                      examination by veterinary practitioners did not always reflect reported histopathological changes. No macroscopic abnormalities were seen in 78\/185 (42%) of rabbit haemorrhagic disease cases. Rapid death and death of other rabbits in the household were common features of rabbit haemorrhagic disease.\n                      <jats:italic>Ante mortem<\/jats:italic>\n                      clinical signs included anorexia, collapse, lethargy, seizures, icterus, bleeding from the mouth, dyspnoea, hypothermia, pyrexia, bradycardia or poor blood clotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Importance<\/jats:title>\n                    <jats:p>Rabbit haemorrhagic disease can be suspected from a history of sudden death, especially if multiple rabbits are affected. There is not always macroscopic evidence of the disease but histopathology is useful to support or refute a diagnosis of rabbit haemorrhagic disease and provide information about other causes of death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.13141","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T05:11:59Z","timestamp":1588914719000},"page":"419-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["<scp>RHDV2<\/scp>\n                    epidemic in\n                    <scp>UK<\/scp>\n                    pet rabbits. Part 1: clinical features, gross\n                    <i>post mortem<\/i>\n                    and histopathological findings"],"prefix":"10.1111","volume":"61","author":[{"given":"N.","family":"Harcourt\u2010Brown","sequence":"first","affiliation":[{"name":"North Yorkshire  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Silkstone","sequence":"additional","affiliation":[{"name":"Abbey Veterinary Services  Newton Abbot UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Whitbread","sequence":"additional","affiliation":[{"name":"Abbey Veterinary Services  Newton Abbot UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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