{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T04:25:05Z","timestamp":1745814305224},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T00:00:00Z","timestamp":1595721600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine azithromycin concentration in severely inflamed canine external ear canals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Five dogs of various breeds and ages with severe and chronic otitis externa underwent ear canal reconstruction surgery. A single oral dose of azithromycin at 10\u2009mg\/kg was administered 12 to 24\u2009hours prior to surgery. Tissue samples were collected from the excised external ear canals and azithromycin concentration was determined using a liquid chromatography\u2010tandem mass spectrometry method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Azithromycin concentrations ranging from 11.4 to 107.0\u2009\u03bcg\/g (mean 59.2\u2009\u00b1\u200944.6\u2009\u03bcg\/g, median 50.9\u2009\u03bcg\/g) were detected in the chronically infected external ear canal tissue 12 to 24\u2009hours after administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Little information exists on antibiotic concentrations in pathological tissues of dogs. Macrolides are known to concentrate in skin tissue. In light of the present results, investigation of clinical efficacy of azithromycin in chronic canine otitis externa is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13179","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:49:07Z","timestamp":1595810947000},"page":"416-418","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Azithromycin concentration in severely inflamed canine external ear canals \u2013 a case series"],"prefix":"10.1111","volume":"61","author":[{"given":"E.","family":"Perry","sequence":"first","affiliation":[{"name":"Veterinary Teaching Hospital, The Koret School of Veterinary Medicine The Hebrew University of Jerusalem, 1 Herzl Street  PO Box 12, Rehovot 7610001 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lavy","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, The Koret School of Veterinary Medicine The Hebrew University of Jerusalem, 1 Herzl Street  PO Box 12, Rehovot 7610001 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Soback","sequence":"additional","affiliation":[{"name":"National Residue Control Laboratory Kimron Veterinary Institute, Veterinary Services, Ministry of Agriculture  5020000 Beit Dagan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Britzi","sequence":"additional","affiliation":[{"name":"National Residue Control Laboratory Kimron Veterinary Institute, Veterinary Services, Ministry of Agriculture  5020000 Beit Dagan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Zur","sequence":"additional","affiliation":[{"name":"National Residue Control Laboratory Kimron Veterinary Institute, Veterinary Services, Ministry of Agriculture  5020000 Beit Dagan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50076-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.12.1948"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01011-06"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00852-06"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01975835"},{"key":"e_1_2_5_7_1","first-page":"724","volume-title":"Small Animal Dermatology","author":"Miller W. 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