{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:10:15Z","timestamp":1776132615677,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009449","name":"Petplan Charitable Trust","doi-asserted-by":"publisher","award":["S18\u2010675\u2010713"],"award-info":[{"award-number":["S18\u2010675\u2010713"]}],"id":[{"id":"10.13039\/100009449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate serological markers of gluten sensitivity in conjunction with cholecystokinin measurement in Border terriers with gall bladder mucocoeles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records from two referral hospitals were obtained between 2011 and 2019 to identify Border terriers with gall bladder mucocoeles, non\u2010Border terriers with gall bladder mucocoeles and control Border terriers with non\u2010biliary diseases. Enzyme\u2010linked immunosorbent assays were performed on stored fasted serum samples for anti\u2010gliadin IgG, anti\u2010canine transglutaminase\u20102\u2010IgA autoantibodies and cholecystokinin. Statistical analysis was performed using the Kruskall\u2010Wallis test to identify differences between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen Border terriers with gall bladder mucocoeles, 17 non\u2010Border terriers with gall bladder mucocoeles and 14 control Border terriers with non\u2010biliary diseases were recruited. Median transglutaminase\u20102\u2010IgA autoantibodies in Border terriers with gall bladder mucocoeles was 0.73 (range: 0.18 to 1.67), which was significantly greater than in control Border terriers at 0.41 (0.07 to 1.14). Median cholecystokinin concentration in Border terriers with gall bladder mucocoeles was 13\u2009pg\/mL (6 to 45 pg\/mL), which was significantly lower than in control Border terriers at 103\u2009pg\/mL (9 to 397 pg\/mL). There was no difference in the anti\u2010gliadin IgG between these groups. There was no difference observed in the non\u2010Border terriers with gall bladder mucocoeles with either of the other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Reduced cholecystokinin and increased transglutaminase\u20102\u2010IgA autoantibodies was detected in Border terriers with gall bladder mucocoeles; which is in part homologous to gall bladder disease identified in human coeliac disease. The results suggest an immunological disease with impaired cholecystokinin release may be affecting gall bladder motility and possibly contributing to mucocoele formation in Border terriers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13211","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T18:10:43Z","timestamp":1599070243000},"page":"630-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles"],"prefix":"10.1111","volume":"61","author":[{"given":"L.","family":"Barker","sequence":"first","affiliation":[{"name":"Bristol Veterinary School University of Bristol  Langford Bristol BS40 5DU UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-9334","authenticated-orcid":false,"given":"M. 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