{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:07:59Z","timestamp":1790618879840,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of a high fat meal (fat loading) on gastrointestinal motility and the appearance of intestinal villi using video capsule endoscopy and ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Four healthy staff\u2010owned dogs were included in a prospective blinded crossover study. Dogs had initial baseline video capsule endoscopy to measure gastrointestinal transit times and allow for visual assessment of intestinal mucosa. Abdominal ultrasound was also performed to obtain intestinal wall measurements and assess for the presence of mucosal hyperechoic speckling. All dogs had diagnostics repeated twice between one and two hours after ingestion of either corn oil or dairy cream for a total of four control and 16 fat loaded studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dogs in the corn oil group had greater mean gastric emptying times (740.3 \u00b1 187.6 minutes vs. 237.9 \u00b1 155 minutes) and total transit times (54.50 \u00b1 22.2 hours vs. 23.25 \u00b1 6.1 hours) than controls. Feeding of a fatty meal resulted in substantial retention of the capsules (10 of 16) within the stomach. While intestinal wall thickness of fat loaded dogs did not differ from control dogs, mucosal hyperechoic speckling scores of the duodenum of dairy cream dogs were greater when compared to control dogs (1.625 \u00b1 0.518 vs. 0.500 \u00b1 0.577).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Data from this pilot study provides further evidence that feeding of a small high fat meal results in ultrasonographic as well as visual changes to the intestinal mucosa of healthy dogs. This data suggests that previous recommendations to feed fatty meals to dogs with lymphangiectasia might not allow differentiation with healthy individuals. In addition, due to the marked effect on gastric emptying time, video capsule endoscopy should be avoided in dogs fed a high fat meal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13216","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T18:40:11Z","timestamp":1602268811000},"page":"732-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A pilot study on the effect of<scp>fat loading<\/scp>on the gastrointestinal tract of healthy dogs"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-708X","authenticated-orcid":false,"given":"J.\u2010S.","family":"Palerme","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Iowa State University Ames IA 50011 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Silverstone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Iowa State University Ames IA 50011 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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