{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:22:56Z","timestamp":1777587776534,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the clinicopathological findings and outcomes of cases of feline congenital hypothyroidism diagnosed in a single veterinary hospital in Santiago, Chile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records were searched for cases of congenital hypothyroidism over an 18\u2010month period. Inclusion criteria were a diagnosis of congenital hypothyroidism based on consistent historical and clinical findings, a low or low\u2010normal serum total T4 and elevated serum canine TSH (cTSH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six unrelated cats ranging in age from 4 to 19\u2009months met the inclusion criteria. The most common historical signs were small stature and lethargy. All cats had disproportionate dwarfism, delayed tooth eruption, retained deciduous teeth, bilateral palpable goitres and low rectal temperatures. Other findings were bradycardia, obesity, poor hair coat and focal alopecia on the ventral aspects of the elbows and hocks. In all cases, cTSH was markedly elevated. Sequential changes noted after the initiation of therapy included normal T4 after 6\u2009weeks, improved hair coat and increased physical activity by 8\u2009weeks, normal cTSH by 10\u2009weeks and normal physical appearance and dentition after 4\u00a0months. Goitres shrank markedly but remained palpable. Hypothyroidism was well managed clinically in all cases 2\u2009years after diagnosis except for one cat that died of unrelated causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>This is the first report to describe a cluster of congenital hypothyroidism cases in non\u2010related cats that were presented over a short period of time. Growth defects resolve with treatment, even in cats diagnosed after puberty. Larger, prospective multi\u2010centre studies are warranted to determine the incidence of congenital hypothyroidism in cats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13231","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T03:39:48Z","timestamp":1601005188000},"page":"696-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cluster of cases of congenital feline goitrous hypothyroidism in a single hospital"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-9168","authenticated-orcid":false,"given":"M. P.","family":"Iturriaga","sequence":"first","affiliation":[{"name":"Escuela de Medicina Veterinaria Facultad de Medicina Veterinaria y Agronom\u00eda, Universidad de Las Am\u00e9ricas, Manuel Montt 948, Providencia  Santiago 7500975 Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Cocio","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Veterinario Universidad de Chile, Francisco Bilbao 2854, Providencia  Santiago 7510828 Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. R.","family":"Barrs","sequence":"additional","affiliation":[{"name":"Jockey Club College of Veterinary Medicine and Life Sciences, Department of Veterinary Clinical Sciences City University of Hong Kong, 31 To Yuen St  Kowloon Tong Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"753","article-title":"Goitrous hypothyroidism and dwarfism in a kitten","volume":"20","author":"Arnold U.","year":"1984","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.07.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2011.567964"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/tvjl.2000.0523"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2001.9695117"},{"key":"e_1_2_6_7_1","first-page":"168","article-title":"Congenital hypothyroidism in a cat","volume":"45","author":"Crowe A.","year":"2004","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.01015.x"},{"key":"e_1_2_6_9_1","first-page":"606","article-title":"Challenging cases in internal medicine: what's your diagnosis?","volume":"95","author":"Firth M.","year":"2000","journal-title":"Veterinary Medicine"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/089875649100800402"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12283"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4067\/S0370-41062012000500011","article-title":"Hipotiroidismo cong\u00e9nito: un diagn\u00f3stico que no debemos olvidar","volume":"83","author":"Grob F.","year":"2012","journal-title":"Revista chilena de pediatr\u00eda"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898756418785946"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.131.7.145"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/vetreccr-2015-000282"},{"key":"e_1_2_6_16_1","first-page":"1","article-title":"Congenital hypothyroidism and concurrent renal insufficiency in a kitten","volume":"85","author":"Lim C. 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