{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:27:40Z","timestamp":1770226060127,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Imerslund\u2010Gr\u00e4sbeck syndrome is an autosomal recessive disease reported only in certain pure\u2010breed dogs. An 18\u2010month\u2010old, male neutered beagle cross\u2010breed was presented for evaluation of severe lethargy, progressive weakness and anorexia. Main clinicopathological findings included low body condition score (2.5\/9), severe muscle atrophy, several neurological abnormalities, mild normochromic, normocytic, non\u2010regenerative anaemia, severe hypocobalaminemia and mild proteinuria. Extensive diagnostic tests ruled out most of differential diagnoses for the aforementioned clinicopathological abnormalities and genetic evaluation showed that the dog was heterozygous for two previously described mutations affecting the <jats:italic>CUBN<\/jats:italic> gene, the beagle and the border collie variants. The dog showed an excellent clinical response to oral cobalamin supplementation with no relapse after 4\u00a0months. In conclusion, this case creates awareness that Imerslund\u2010Gr\u00e4sbeck syndrome should be considered even in mixed\u2010breed dogs with compatible clinical signs and that two different pathogenic <jats:italic>CUBN<\/jats:italic> mutations in compound heterozygosity can lead to a typical Imerslund\u2010Gr\u00e4sbeck syndrome phenotype.<\/jats:p>","DOI":"10.1111\/jsap.13239","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T21:24:14Z","timestamp":1602019454000},"page":"709-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>Imerslund\u2010Grasbeck syndrome<\/scp> in a cross\u2010breed dog"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-8185","authenticated-orcid":false,"given":"I. 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