{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:32:47Z","timestamp":1695987167036},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>O<jats:sc>bjectives<\/jats:sc><\/jats:title><jats:p>To describe the incidence, severity and progression of proteinuria over the first 6\u00a0months of masitinib treatment in tumour\u2010bearing dogs without pre\u2010existing proteinuria. To describe the effect of treatment on urine protein:creatinine and renal parameters in patients with pre\u2010existing proteinuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>M<jats:sc>aterials and<\/jats:sc> M<jats:sc>ethods<\/jats:sc><\/jats:title><jats:p>Records were reviewed from patients receiving masitinib for neoplasms between June 1, 2010, and May 5, 2019. Patients without pre\u2010treatment and at least one urine protein:creatinine after \u22657\u2009days treatment were excluded. Signalment, tumours and concurrent diseases, treatments, haematology, biochemistry and urinalysis results before, during and after treatment for up to 202\u2009days were collected. Patient visits were grouped into six timepoints for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>R<jats:sc>esults<\/jats:sc><\/jats:title><jats:p>Twenty\u2010eight dogs were included. Eighteen percent of dogs non\u2010proteinuric at baseline (four of 22) developed proteinuria during treatment, all within 1\u00a0month of treatment initiation. One dog developed hypoalbuminaemia, none developed oedema or ascites, azotaemia or were euthanased\/died due to proteinuria. Masitinib was immediately discontinued in both dogs in which urine protein:creatinine greater than 2.0 was detected and in both, proteinuria improved.<\/jats:p><jats:p>Six dogs with pre\u2010treatment proteinuria were treated with masitinib, significant worsening of proteinuria did not occur. Neither azotaemia nor severe hypoalbuminaemia occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>C<jats:sc>linical<\/jats:sc> S<jats:sc>ignificance<\/jats:sc><\/jats:title><jats:p>Proteinuria, when it occurs, tends to develop within 1\u00a0month of masitinib commencement and may progress rapidly. Weekly proteinuria monitoring should be considered for the first month and a urine protein:creatinine greater than 0.5 should prompt reassessment within 1\u00a0week. Masitinib treatment can be considered in patients with pre\u2010treatment proteinuria and does not inevitably cause worsening of proteinuria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13305","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T05:00:03Z","timestamp":1614315603000},"page":"646-654","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and progression of proteinuria in dogs treated with masitinib for neoplasia: 28 cases (2010\u20102019)"],"prefix":"10.1111","volume":"62","author":[{"given":"M.","family":"Kuijlaars","sequence":"first","affiliation":[{"name":"Small Animal Hospital University of Glasgow  Glasgow Scotland G611QH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Helm","sequence":"additional","affiliation":[{"name":"Small Animal Hospital University of Glasgow  Glasgow Scotland G611QH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"McBrearty","sequence":"additional","affiliation":[{"name":"Small Animal Hospital University of Glasgow  Glasgow Scotland G611QH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"AB Science \u201cMasivet: masitinib package leaflet \u201d 2018\u201011\u201016\/uk01.01 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