{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:58:05Z","timestamp":1790330285572,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aims of this study were to evaluate taurine levels in English cocker spaniels with dilated cardiomyopathy and assess their survival time and natural progression of their disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Retrospective comparison of English cocker spaniels with dilated cardiomyopathy phenotype with and without taurine deficiency at the cardiology department of a UK academic referral centre between 2008 and 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Taurine plasma concentration was available in 16 English cocker spaniels with dilated cardiomyopathy phenotype; 13 of 16 had congestive heart failure and three of 16 did not. Taurine concentration was low (&lt;50\u2009\u03bcmol\/L) in 13 of 16 and normal in three of 16. Deficient dogs received taurine supplementation in addition to conventional cardiac medications. Eight dogs were still alive at the end of this study and eight were dead. MST for all dogs included in the study was 2800\u2009days. Left ventricular systolic function improved and left ventricular dimensions reduced in English cocker spaniels with taurine deficiency following taurine supplementation and conventional cardiac therapy, although similar results were observed in English cocker spaniels with normal taurine concentration on cardiac therapy alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Based on laboratory reference intervals, low taurine concentrations were common in English cocker spaniels with dilated cardiomyopathy, showing a possible association between dilated cardiomyopathy in English cocker spaniels and taurine deficiency; supplementation with taurine was not curative.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13306","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T05:11:55Z","timestamp":1613797915000},"page":"570-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Low plasma taurine levels in English cocker spaniels diagnosed with dilated cardiomyopathy"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9824-8992","authenticated-orcid":false,"given":"M.","family":"Basili","sequence":"first","affiliation":[{"name":"Cardiology Service, Small Animal Teaching Hospital Institute of Infection, Veterinary and Ecological Science, University of Liverpool Neston Chester CH64 7TE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Pedro","sequence":"additional","affiliation":[{"name":"Cardiology Service, Small Animal Teaching Hospital Institute of Infection, Veterinary and Ecological Science, University of Liverpool Neston Chester CH64 7TE UK"},{"name":"Cardiology Service Willows Veterinary Centre and Referral Service Shirley Solihull B90 4NH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hodgkiss\u2010Geere","sequence":"additional","affiliation":[{"name":"Cardiology Service, Small Animal Teaching Hospital Institute of Infection, Veterinary and Ecological Science, University of Liverpool Neston Chester CH64 7TE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Navarro\u2010Cubas","sequence":"additional","affiliation":[{"name":"Cardiology Service, Small Animal Teaching Hospital Institute of Infection, Veterinary and Ecological Science, University of Liverpool Neston Chester CH64 7TE UK"},{"name":"Cardiology Service Southfields Veterinary Specialists Basildon Essex SS15 6TP UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Graef","sequence":"additional","affiliation":[{"name":"Cardiology Service, Small Animal Teaching Hospital Institute of Infection, Veterinary and Ecological Science, University of Liverpool Neston Chester CH64 7TE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dukes\u2010McEwan","sequence":"additional","affiliation":[{"name":"Cardiology Service, Small Animal Teaching Hospital Institute of Infection, Veterinary and Ecological Science, University of Liverpool Neston Chester CH64 7TE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15331"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-004-0149-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.56.95"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.10.2525"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/0410284"},{"key":"e_1_2_5_7_1","first-page":"139","volume-title":"Manual of Veterinary Echocardiography","author":"Boon J. A.","year":"1998"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14586"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2011.11.005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb02551.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0396.2003.00433.x"},{"key":"e_1_2_5_12_1","first-page":"365","article-title":"Dilated cardiomyopathy (DCM) in Newfoundland dogs: association with low whole blood taurine level","volume":"42","author":"Dukes\u2010McEwan J.","year":"2001","journal-title":"Journal of Small Animal Practice"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1760-2734(06)70047-9"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/inpract.22.10.620"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12841"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.4.751"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.1137"},{"key":"e_1_2_5_18_1","volume-title":"Cocker Spaniel, American & English","author":"Fogle B.","year":"1996"},{"key":"e_1_2_5_19_1","first-page":"646","volume-title":"Kirk & Bistner's Handbook of Veterinary Procedures and Emergency Treatment","author":"Ford R. B.","year":"2011"},{"key":"e_1_2_5_20_1","first-page":"581","volume-title":"Textbook of Canine and Feline Cardiology: Principles and Clinical Practice","author":"Fox P. R.","year":"1999"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.253.11.1390"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1997.tb11253.x"},{"key":"e_1_2_5_23_1","first-page":"1978","article-title":"Echocardiographic characterization of dilatation cardiomyopathy in the English cocker spaniel","volume":"47","author":"Gooding J. P.","year":"1986","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1982.tb01651.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12181"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/122.4.1019"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209112"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00092.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.5.1171"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1995.tb01076.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2002.tb02366.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2008.00659.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2004.05.003"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1995.tb03266.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233206"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2011.09.003"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3616607"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1072"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2006.08.010"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2001.tb01238.x"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0592.x"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00592-X"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12984"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.01026.x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1987.tb03881.x"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1994.tb01588.x"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-33-4-364"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0396.2003.00446.x"},{"key":"e_1_2_5_49_1","first-page":"98","article-title":"Myocardial diseases of animals","volume":"124","author":"Van Vleet J. F.","year":"1986","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvc.2013.03.005"},{"key":"e_1_2_5_51_1","unstructured":"Wotton P. R.(1998)Cardiomyopathy in English cocker and springer spaniels: a review of 38 cases. Proceedings of the British Small Animal Veterinary Association p316"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.13306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsap.13306","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.13306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:53:50Z","timestamp":1693353230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.13306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,16]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/jsap.13306"],"URL":"https:\/\/doi.org\/10.1111\/jsap.13306","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,16]]},"assertion":[{"value":"2020-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}