{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:15:36Z","timestamp":1779297336626,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the correlation between gallbladder wall thickness and serum\/plasma albumin concentrations in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Retrospective searches of digital medical record databases were conducted to identify dogs that had either severely low serum\/plasma albumin concentration (&lt;1.5 g\/dL) or ultrasonographic evidence of gallbladder wall thickening (&gt;2 mm). Analysis of covariance models were used to analyze gallbladder wall thickness with sample type (serum vs plasma), age, etiology, albumin, and albumin ' etiology as the covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 216 dogs met inclusion criteria. One\u2010hundred and forty\u2010six dogs had a thickened gallbladder wall (Group 1). Median serum\/plasma albumin concentration for dogs in this group was 2.2 g\/dL (1 to 5 g\/dL), and 84 dogs (57.5%) had hypoalbuminemia (&lt;2.5 g\/dL). The search for dogs with severe hypoalbuminemia (&lt; 1.5 g\/dL) identified 70 dogs (Group 2). In this group, median gallbladder wall thickness was 1.3 mm (0.2 to 6.1 mm) and 17 dogs (24.3%) had a thickened gallbladder wall. Serum\/plasma albumin concentration and gallbladder wall thickness were not significantly correlated for Group 1 (r = 0.0044, p = 0.9580) or Group 2 (r = \u20100.1137, p = 0.3487). A moderate negative correlation (\u20100.64) was identified between gallbladder wall thickness and albumin concentration in dogs with immune\u2010mediated diseases (p = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Gallbladder wall thickness and serum\/plasma albumin concentration are independent variables in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13358","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T05:19:31Z","timestamp":1626153571000},"page":"973-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of the association between gall bladder wall thickness and hypoalbuminaemia in dogs"],"prefix":"10.1111","volume":"62","author":[{"given":"J.","family":"Sparago","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Louisiana State University School of Veterinary Medicine 1909 Skip Bertman Drive Baton Rouge LA 70803 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rademacher","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Louisiana State University School of Veterinary Medicine 1909 Skip Bertman Drive Baton Rouge LA 70803 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dehghanpir","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Louisiana State University School of Veterinary Medicine 1909 Skip Bertman Drive Baton Rouge LA 70803 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Louisiana State University School of Veterinary Medicine 1909 Skip Bertman Drive Baton Rouge LA 70803 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-8313","authenticated-orcid":false,"given":"C. 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