{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:49:40Z","timestamp":1773013780837,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the diagnostic accuracy of ultrasonography in the detection of lymphomatous infiltration of the liver and spleen in a population of dogs and cats with lymphoma. To determine if specific ultrasonographic features of the liver and spleen in dogs are associated with lymphomatous infiltration or a specific immunophenotype of multi\u2010centric lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A blinded retrospective evaluation of ultrasonographic images of the liver and\/or spleen in dogs and cats with cytologically or histologically confirmed lymphoma was performed by two board\u2010certified veterinary radiologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 161 animals met the inclusion criteria, comprising 132 dogs and 29 cats. Ultrasonography had a sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 16.7%, 91.0%, 55.9%, 62.5% and 55.0% for the detection of lymphomatous infiltration of the liver, and 73.1%, 93.9%, 82.6%, 93.4% and 74.7% for the spleen. In dogs, an ultrasonographically normal liver was associated with not having lymphomatous infiltration, leopard\u2010spotted splenic parenchyma and splenomegaly were independently associated with lymphomatous infiltration and leopard\u2010spotted splenic parenchyma was also associated with the B cell immunophenotype of multi\u2010centric lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Ultrasonography of the spleen and liver is specific but not sensitive in the detection of lymphomatous infiltration. A leopard\u2010spotted splenic parenchyma in dogs is highly specific for lymphomatous infiltration and in this population predicted a specific immunophenotype of multi\u2010centric lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13438","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T23:24:09Z","timestamp":1633735449000},"page":"113-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic accuracy of ultrasonography to detect hepatic and splenic lymphomatous infiltration in dogs and cats"],"prefix":"10.1111","volume":"63","author":[{"given":"J. C.","family":"Sumping","sequence":"first","affiliation":[{"name":"Small Animal Teaching Hospital University of Liverpool Leahurst Campus, Cheshire CH64 7TE UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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