{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:39:13Z","timestamp":1784896753230,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Report the rate of recurrent clinical signs following successful treatment of cervical intervertebral disc extrusion, and explore the association between treatment method and recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Medical records of dogs with MRI\u2010 or CT\u2010confirmed cervical intervertebral disc extrusion were reviewed to verify that they recovered. Type of treatment, site of initial extrusion and whether dogs re\u2010presented with recurrent clinical signs were recorded. Recurrence was considered presumed if based on clinical signs or confirmed if based on repeat cross\u2010sectional imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete recovery was documented following medical (36\/119, 30.3%) or surgical (83\/119, 69.7%) management of initial cervical disc extrusion. There was a recurrence of consistent clinical signs in 40 of 119 (34%) cases, of which 27 of 83 (33%) were initially managed surgically and 13 of 36 (36%) medically. In 24 of 40 (60%) cases, there was imaging confirmation of recurrent extrusion; in medically managed dogs, recurrence mostly occurred at the same site, whereas after surgery, recurrence most commonly involved an adjacent disc. Of the 40 recurrences, 32 (80%) occurred within 2\u2009years of diagnosis. Rate of recurrence was similar between treatment methods in both univariable and multivariable time\u2010to\u2010event analyses (hazard ratio 1.03; 95% confidence interval: 0.67 to 1.53; P=0.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Following successful initial medical or surgical treatment, clinical signs consistent with recurrent cervical disc extrusion occurred with similar frequency. Medically treated cases tended to have recurrence at the same site as initial presentation, whereas surgical treatment prevented this. Recurrence usually occurred within 2\u2009years. The retrospective study design, small number of recurrences and lack of imaging confirmation of every recurrence should be considered when interpreting the results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13480","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T06:53:41Z","timestamp":1644562421000},"page":"454-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Recurrence of signs consistent with cervical intervertebral disc extrusion in dogs"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8830-9605","authenticated-orcid":false,"given":"V.","family":"Argent","sequence":"first","affiliation":[{"name":"Department of Small Animal Neurology Davies Veterinary Specialists  Higham Gobion SG5 3HR UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Perillo","sequence":"additional","affiliation":[{"name":"Department of Small Animal Neurology Clinica Veterinaria San Marco, Viale dell'Industria  Veggiano 35030 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Jeffery","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Texas A&amp;M University  College Station TX 77843 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-5573","authenticated-orcid":false,"given":"P.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Small Animal Neurology Queen's Veterinary School Hospital  Cambridge CB3 0ES UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2012.00970.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2010.06.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118711545.ch22"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.238.12.1593"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1709082114"},{"key":"e_1_2_5_7_1","unstructured":"Canine HealthCheck. 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