{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:28:06Z","timestamp":1788564486979,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To determine the incidence of clinical signs and\n                      <jats:italic>Vitis<\/jats:italic>\n                      fruit\u2010induced acute kidney injury in dogs and cats with a\n                      <jats:italic>Vitis<\/jats:italic>\n                      fruit ingestion reported to the Dutch Poisons Information Center, and a description of the therapies instituted by the veterinarians.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>All cases of Vitis fruit ingestions in dogs and cats reported to the center between January 1, 2018 and December 31, 2018 were included in this study. Veterinarians and pet owners were contacted by phone or email to obtain follow\u2010up information. Information was collected using a standardised data collection sheet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010five dogs and 13 cats with proven\n                      <jats:italic>Vitis<\/jats:italic>\n                      fruit ingestion were included. Fourteen dogs and\u00a0two cats developed clinical signs: emesis (11\/16, 68.8%), lethargy (5\/16, 31.3%), diarrhoea (3\/16, 18.8%), anorexia (3\/16, 18.8%), tremor (2\/16, 12.5%) and restlessness (1\/16, 6.3%). The\u00a0overall incidence for developing clinical signs was 14.7% in dogs and 15.4% in cats. One (1\/95, 1%) dog developed acute kidney injury after ingestion of\n                      <jats:italic>Vitis<\/jats:italic>\n                      fruit. No cats developed acute kidney injury. Induction of emesis and\/or administration of activated charcoal was instituted in 72 of 82 (88%) and eight of 11 (73%) of asymptomatic dogs and cats and six of 14 (43%) and two of two (100%) of symptomatic dogs and cats, respectively. Overall, emesis was induced in 72 of 95 (76%) dogs (100% success rate) and removed\n                      <jats:italic>Vitis<\/jats:italic>\n                      fruits in the majority of cases (98% when induced &lt;4\u00a0hours after ingestion and 83% when induced 4 to 12\u2009hours after ingestion). Emesis was induced in seven of 13 (54%) cats (86% success rate) and removed\n                      <jats:italic>Vitis<\/jats:italic>\n                      fruits in 83% of the cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>\n                      In this study, a significant proportion (around 15%) of dogs and cats developed clinical signs after ingestion of\n                      <jats:italic>Vitis<\/jats:italic>\n                      fruits, which were predominantly related to the gastrointestinal tract. Symptomatic acute kidney injury was rare. Our findings suggest the use of decontamination measures,\n                      <jats:italic>i.e.<\/jats:italic>\n                      induction of emesis, may be warranted up to 12\u2009hours after ingestion.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jsap.13483","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T02:54:51Z","timestamp":1644375291000},"page":"447-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incidence of\n                    <scp>\n                      <i>Vitis<\/i>\n                    <\/scp>\n                    fruit\u2010induced clinical signs and acute kidney injury in dogs and cats"],"prefix":"10.1111","volume":"63","author":[{"given":"M. A.","family":"Dijkman","sequence":"first","affiliation":[{"name":"Dutch Poisons Information Center University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"van Roemburg","sequence":"additional","affiliation":[{"name":"Section of Emergency and Intensive Care Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University PO Box 80.154 NL\u20103584 CM Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"De Lange","sequence":"additional","affiliation":[{"name":"Dutch Poisons Information Center University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hugen","sequence":"additional","affiliation":[{"name":"Section of Emergency and Intensive Care Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University PO Box 80.154 NL\u20103584 CM Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Robben","sequence":"additional","affiliation":[{"name":"Section of Emergency and Intensive Care Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine Utrecht University PO Box 80.154 NL\u20103584 CM Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-3862.2007.tb00121.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13025"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02744.x"},{"key":"e_1_2_5_5_1","first-page":"1555","article-title":"Renal failure associated with ingestion of grapes or raisins in dogs","volume":"218","author":"Gwaltney\u2010Brant S.","year":"2001","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_6_1","first-page":"30","article-title":"Orale Vergiftigingen bij de hond en kat. 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(2015)Feiten & Cijfer Gezelschapsdierensector 2015"},{"key":"e_1_2_5_15_1","first-page":"706","article-title":"Unique sensitivity of dogs to tartaric acid and implications for toxicity of grapes","volume":"258","author":"Wegenast C.","year":"2021","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10071162"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.13483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsap.13483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsap.13483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T06:28:14Z","timestamp":1692858494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.13483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/jsap.13483"],"URL":"https:\/\/doi.org\/10.1111\/jsap.13483","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,8]]},"assertion":[{"value":"2021-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}