{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:45:52Z","timestamp":1777484752830,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T00:00:00Z","timestamp":1662854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to re\u2010evaluate the low\u2010dose dexamethasone suppression test 8\u2010hour cortisol cut\u2010point for the diagnosis of hypercortisolism in dogs using a solid\u2010phase, competitive chemiluminescent enzyme immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010seven client\u2010owned dogs with naturally occurring hypercortisolism and 30 healthy control dogs were prospectively recruited. Performance of the low\u2010dose dexamethasone suppression test was assessed using sensitivity, specificity and a receiver operating characteristic curve compared to a clinical diagnosis of hypercortisolism including response to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four dogs were diagnosed with pituitary\u2010dependent hypercortisolism and three with adrenal\u2010dependent hypercortisolism. In 30 healthy control dogs, 8\u2010hour post\u2010dexamethasone cortisol concentrations ranged from 5.5 to 39\u2009nmol\/L. A receiver operating characteristic curve curve constructed from the 8\u2010hour post\u2010dexamethasone cortisol concentrations of hypercortisolism and control dogs demonstrated that the most discriminatory cut\u2010point was more than 39\u2009nmol\/L with sensitivity of 85.2% (95% confidence interval, 67.5% to 94.1%) and specificity of 100% (95% confidence interval, 88.7% to 100.0%) and an area under the curve of 0.963.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The optimal cut\u2010point of more than 36\u2009nmol\/L proposed by this study is similar to the currently accepted 8\u2010hour cortisol concentration cut\u2010point for diagnosing hypercortisolism when using a solid\u2010phase, competitive chemiluminescent enzyme immunoassay.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13553","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T01:29:58Z","timestamp":1662946198000},"page":"12-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Re\u2010evaluation of the low\u2010dose dexamethasone suppression test in dogs"],"prefix":"10.1111","volume":"64","author":[{"given":"L.","family":"Lim","sequence":"first","affiliation":[{"name":"Veterinary Medical Teaching Hospital University of California\u2010Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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