{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:41:40Z","timestamp":1783762900709,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterise the fever episodes attributed to Shar Pei autoinflammatory disease and to identify common diagnostic and management strategies in the United Kingdom. A secondary objective was to determine risk factors associated with Shar Pei autoinflammatory disease fever episodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective survey was performed to characterise episodes of Shar Pei autoinflammatory disease fever and to identify commonly used treatments in affected dogs. Clinical data were collected from owners and veterinarians. Frequencies of previously proposed risk factors (skin thickness and folding, muzzle conformation) and comorbid conditions were compared between dogs that had exhibited fever episodes consistent with Shar Pei autoinflammatory disease and those who had not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At least one episode of fever attributed to Shar Pei autoinflammatory disease was reported in 52 of 106 (49%) Shar Pei. Nine other dogs had fever episodes consistent with Shar Pei autoinflammatory disease reported by their owners but not by veterinarians. Median rectal temperature at presentation for Shar Pei autoinflammatory disease fever was 40.1\u00b0C [104.2\u00b0F] (39.9 to 41.3\u00b0C [103.8 to 106.3\u00b0F]) and owners reported associated hyporexia (n=33, 63%) and vomiting (n=8, 15%) more frequently than veterinary records (n=22, 42% and n=0, 0%, respectively). The median number of veterinary appointments for Shar Pei autoinflammatory disease was two per dog (1 to 15) while owners reported a median of four episodes per dog per year. None of the assessed phenotypic variants or comorbidities were significantly associated with exhibiting Shar Pei autoinflammatory disease fever episodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Episodes of Shar Pei autoinflammatory disease fever were reported approximately twice as frequently by owners compared to veterinary records, suggesting the burden of this condition may be underestimated by veterinarians. Specific risk factors for Shar Pei autoinflammatory disease fever were not identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13602","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T03:34:55Z","timestamp":1680060895000},"page":"401-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A survey on Shar Pei autoinflammatory disease in the United Kingdom"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-7841","authenticated-orcid":false,"given":"M.","family":"Work","sequence":"first","affiliation":[{"name":"Willows Veterinary Centre and Referral Service  Solihull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-9893","authenticated-orcid":false,"given":"C.","family":"Scudder","sequence":"additional","affiliation":[{"name":"Southfields Veterinary Specialists  Essex UK"},{"name":"Royal Veterinary College  Potters Bar Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bergum Hjellegjerde","sequence":"additional","affiliation":[{"name":"Anderson Moores Veterinary Specialists  Hampshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dunning","sequence":"additional","affiliation":[{"name":"Willows Veterinary Centre and Referral Service  Solihull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Gajanayake","sequence":"additional","affiliation":[{"name":"Willows Veterinary Centre and Referral Service  Solihull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-5893","authenticated-orcid":false,"given":"A.","family":"Kent","sequence":"additional","affiliation":[{"name":"Willows Veterinary Centre and Referral Service  Solihull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tintle","sequence":"additional","affiliation":[{"name":"Wurtsboro Veterinary Clinic  Wurtsboro New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sparks","sequence":"additional","affiliation":[{"name":"Waltham Petcare Science Institute  Leicestershire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Allerton","sequence":"additional","affiliation":[{"name":"Willows Veterinary Centre and Referral Service  Solihull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"100","volume-title":"British Small Animal Veterinary Association Small Animal Formulary","author":"Allerton F.","year":"2020"},{"key":"e_1_2_5_3_1","unstructured":"Animal Health Diagnostic Center. 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