{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:51Z","timestamp":1787840811328,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to determine the response time to immunosuppressive therapy and time required to achieve a 5% increase in haematocrit among dogs with non\u2010regenerative immune\u2010mediated anaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Client\u2010owned dogs diagnosed with non\u2010regenerative immune\u2010mediated anaemia in Hokkaido University Veterinary Teaching Hospital between December 2012 and May 2018 were enrolled. The first treatment regimen included prednisolone (2\u2009mg\/kg\/day) and ciclosporin (up to 10\u2009mg\/kg\/day) for 8\u2009weeks. Dogs that did not respond to the first regimen proceeded to the second regimen comprising prednisolone and mycophenolate mofetil (15\u2009mg\/kg, twice a day). Reticulocyte count and haematocrit were monitored every 1 to 2\u2009weeks. Treatment response was defined as an absolute reticulocyte count more than 60\u00d710<jats:sup>3<\/jats:sup>\/\u03bcL or increasing haematocrit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 23 dogs fulfilled the inclusion criteria for non\u2010regenerative immune\u2010mediated anaemia. Twelve dogs were excluded from this study for various reasons and response to therapy was evaluated in the remaining 11 dogs. Treatment responses were observed in 8 of 11 dogs, and the median time to response was 39.5\u2009days (range 8 to 92\u2009days). Two responders were unable to continue the first treatment regimen and were switched to the second regimen owing to anorexia and nausea, possibly induced by ciclosporin; withdrawal of ciclosporin improved their symptoms. The time required to achieve a 5% increase in haematocrit was assessed in the other six dogs, with a median of 55.5\u2009days (range 8 to 135\u2009days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>Here we report the response to a standardised treatment protocol in dogs with non\u2010regenerative immune\u2010mediated anaemia. Knowledge of potential side effects and expected therapeutic outcomes may be of use for veterinary practitioners treating this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jsap.13614","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T05:37:41Z","timestamp":1680932261000},"page":"527-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of responses to immunosuppressive therapy in dogs with suspected non\u2010regenerative immune\u2010mediated anaemia: 11 cases (2012\u20102018)"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8595-4994","authenticated-orcid":false,"given":"K.","family":"Morishita","sequence":"first","affiliation":[{"name":"Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine, Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-9055","authenticated-orcid":false,"given":"M.","family":"Sugawara\u2010Suda","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine, Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-7869","authenticated-orcid":false,"given":"J.","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine, Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-6586","authenticated-orcid":false,"given":"N.","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine, Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-3228","authenticated-orcid":false,"given":"K.","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine, Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3673-4319","authenticated-orcid":false,"given":"H.","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine Rakuno Gakuen University Ebetsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-7036","authenticated-orcid":false,"given":"M.","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine, Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.255.3.366"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01191.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12367"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1986.tb02245.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2460\/javma.1996.208.02.243","article-title":"Hepatic abscesses in dogs: 14 cases (1982\u20131994)","volume":"208","author":"Farrar E. 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